{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T20:55:51Z","timestamp":1780433751943,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T00:00:00Z","timestamp":1716249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002865","name":"Chongqing Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["cstc2020jscx\u2010dxwtBX0054"],"award-info":[{"award-number":["cstc2020jscx\u2010dxwtBX0054"]}],"id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002865","name":"Chongqing Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["CSTB2022NSCQ\u2010MSX1646"],"award-info":[{"award-number":["CSTB2022NSCQ\u2010MSX1646"]}],"id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012459","name":"Chongqing Graduate Student Research Innovation Project","doi-asserted-by":"publisher","award":["KJQN202215118"],"award-info":[{"award-number":["KJQN202215118"]}],"id":[{"id":"10.13039\/501100012459","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012459","name":"Chongqing Graduate Student Research Innovation Project","doi-asserted-by":"publisher","award":["KJZD\u2010M202215102"],"award-info":[{"award-number":["KJZD\u2010M202215102"]}],"id":[{"id":"10.13039\/501100012459","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytochemical Analysis"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Lysimachia christinae<\/jats:italic> Hance (LCH) is a traditional medicine used to treat gallstone disease and cholecystitis. Despite its known anti\u2010inflammatory and choleretic effects, its quality has not been extensively evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>In this study, we aimed to establish a reliable quality evaluation method for LCH via fingerprint, spectrum\u2013effect relationship, and quantitative analyses of multicomponents by a single marker (QAMS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>First, the fingerprints and anti\u2010inflammatory and choleretic activities of 14 LCH batches were determined. Then, the gray relation analysis method was used to analyze the peak areas of the fingerprint profile and pharmacodynamic data. Subsequently, the characteristic peaks were tentatively identified using high\u2010performance liquid chromatography\u2010quadrupole time\u2010of\u2010flight mass spectrometry. Finally, rutin was selected as the internal reference material, and QAMS was used to analyze the LCH components.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pharmacodynamic experiments confirmed that LCH exerted anti\u2010inflammatory and choleretic effects. Moreover, 15 flavonoids related to the anti\u2010inflammatory and choleretic effects of LCH were identified. Notably, relative error percentage between the QAMS and external standard method was less than 5%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study successfully established a comprehensive evaluation method for the qualitative and quantitative analyses of LCH.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pca.3394","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T20:19:55Z","timestamp":1716322795000},"page":"1527-1536","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Comprehensive quality evaluation of <i>Lysimachia christinae<\/i> Hance via fingerprint, spectrum\u2013effect relationship, and quantitative analyses of multiple components by single marker"],"prefix":"10.1002","volume":"35","author":[{"given":"Quji","family":"LuoRong","sequence":"first","affiliation":[{"name":"College of Traditional Chinese Medicine Chongqing Medical University  Chongqing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Hong","family":"Tan","sequence":"additional","affiliation":[{"name":"College of Pharmacy &amp; College of Traditional Chinese Medicine Chongqing Medical and Pharmaceutical College  Chongqing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine Chongqing College of Traditional Chinese Medicine  Chongqing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingqin","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine Chongqing Medical University  Chongqing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Luo","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese 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