{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:34:56Z","timestamp":1762432496311,"version":"build-2065373602"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012521","name":"Universitas Gadjah Mada","doi-asserted-by":"publisher","award":["5075\/UN1.P.II\/Dit\u2010Lit\/PT.01.01\/2023","31.01.02\/UN1\/FFA.1\/SETPIM\/PT\/2022"],"award-info":[{"award-number":["5075\/UN1.P.II\/Dit\u2010Lit\/PT.01.01\/2023","31.01.02\/UN1\/FFA.1\/SETPIM\/PT\/2022"]}],"id":[{"id":"10.13039\/501100012521","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytochemical Analysis"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Phenolic compounds garner interest in developing medicines, nutraceuticals, and cosmeceuticals based on natural products. The quantity of phenolic compounds in a sample is commonly determined via spectrophotometry; however, this instrumented technique is relatively laborious and time consuming and requires a large amount of reagents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This work aimed to develop a simple, point\u2010of\u2010need colorimetric sensor to rapidly determine total phenolic content (TPC) in tea extracts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>We developed a radial paper\u2010based analytical device (PAD) for TPC determination based on the established colorimetric reaction between the Folin\u2013Cioc\u00e2lteu reagent and phenols. The PAD was designed to enable quantitative (with image capturing device and color processing software) and semiquantitative (using a color palette reference card) determinations. Analytical performance and stability of the PAD were evaluated based on the color responses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The PAD was successfully applied for the determination of phenolics in tea extracts obtained using several polar protic solvents, including water, methanol, and ethanol, with satisfactory accuracy (recovery of 95.5%\u2013104%, 110%\u2013116%, and 104%\u2013110%, respectively) and precision (RSD\u2009&lt;\u20099%). The obtained TPC values also agreed with those from visible spectrophotometry. Semiquantitative determination using the color reference card with three categories of TPC level (i.e., 0\u2013100, 100\u2013500, and 500\u20131000\u2009mg gallic acid equivalent\/L) provided &gt;\u200995% accuracy. The devices were the most stable when stored at 4\u00b0C in a light\u2010protected, vacuum\u2010sealed container. The proposed PAD is promising for simple, rapid (~10\u201320\u2009min), and accurate estimation of TPC in plant extracts.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pca.3494","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T19:15:26Z","timestamp":1735240526000},"page":"1094-1104","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Paper\u2010Based Device for Phenolic Content Determination in Tea Extracts"],"prefix":"10.1002","volume":"36","author":[{"given":"Rachma\u00a0Athaya","family":"Silver","sequence":"first","affiliation":[{"name":"Pharmacy Undergraduate Program, Faculty of Pharmacy Universitas Gadjah Mada  Yogyakarta Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0556-4011","authenticated-orcid":false,"given":"Eka","family":"Noviana","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, 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