{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:29:53Z","timestamp":1777526993903,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T00:00:00Z","timestamp":1740268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174263"],"award-info":[{"award-number":["82174263"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013091","name":"Science and Technology Major Project of Guangxi","doi-asserted-by":"publisher","award":["2022JBGS042"],"award-info":[{"award-number":["2022JBGS042"]}],"id":[{"id":"10.13039\/501100013091","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytochemical Analysis"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Blood stasis syndrome (BSS) is one of the common syndromes in traditional Chinese medicine. The Chinese medicine compound composed of \u201cDanggui\u2010Guizhi (DG\u2010GZ)\u201das the core has the effect of reducing blood stasis and promoting blood circulation. However, the difference of efficacy of DG\u2010GZ traditional decoction and dispensing granules in reducing blood stasis are still unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Investigation of the difference of decoction and dispensing\u00a0granules of Danggui (DG) and Guizhi (GZ) in blood stasis syndrome (BSS) in an animal study (Six groups,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      All rats were randomly divided into six groups: control, model, Danggui\u2014Guizhi dispensed granules (\u00a0DGK\u2013GZK), Danggui\u2014Guizhi decoction (DG\u2013GZ), Danggui granules\u2014Guizhi decoction (DGK\u2013GZ), and Danggui decoction \u2014Guizhi granules (DG\u2010GZK) groups\u00a0(\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096). The blood stasis model was constructed by exposing rats to ice\u2010cold water. Whole blood viscosity (WBV) was used to compare the effects of DG\u2013GZ (4:3\n                      <jats:italic>w<\/jats:italic>\n                      \/\n                      <jats:italic>w<\/jats:italic>\n                      ) decoction and dispensing granules in improving BSS. Metabolomics analysis of urine and 16S rRNA gene sequencing were used to investigate metabolic analysis and gut microbiota changes in rats with BSS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The results of WBV showed that DG\u2010GZ and its granules exhibited efficacy against blood stasis, and the effect of DGK\u2010GZK in relieving blood stasis was greater than that of other administration groups. Urine metabolomics demonstrated that DGK\u2013GZK could reverse the abnormal levels of butyrate, citrate, taurine, creatinine, glucose, and other metabolites in BSS rats. DGK\u2013GZK could promote the enrichment of the\n                      <jats:italic>g__Prevotellaceae<\/jats:italic>\n                      _NK3B31_group,\n                      <jats:italic>g__Ligilactobacillus<\/jats:italic>\n                      , and\n                      <jats:italic>g__Roseburia<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The effect of DGK\u2010GZK intervention in BSS was stronger than that of other compound groups. This study also provides basic experimental data for exploring the difference in efficacy between traditional decoction and dispensing granules.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pca.3518","type":"journal-article","created":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T22:59:32Z","timestamp":1740351572000},"page":"1416-1434","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Metabolomics Analysis of Urine and 16S rRNA Sequencing of Gut Microbiota in Rats With Blood Stasis Syndrome\u00a0After\u00a0Intervention With Danggui\u2010Guizhi Decoction and Dispensing Granules \u00a0"],"prefix":"10.1002","volume":"36","author":[{"given":"Jiwei","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Pharmacy The Second Affiliated Hospital of Guangxi Medical University  Nanning China"},{"name":"Pharmaceutical College Guangxi Medical University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Guangxi Medical University Cancer Hospital  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunyuan","family":"Nong","sequence":"additional","affiliation":[{"name":"Pharmaceutical College Guangxi Medical University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linlin","family":"Feng","sequence":"additional","affiliation":[{"name":"Pharmaceutical College Guangxi Medical University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shulin","family":"Huang","sequence":"additional","affiliation":[{"name":"Pharmaceutical College Guangxi Medical University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3908-3208","authenticated-orcid":false,"given":"Zhiheng","family":"Su","sequence":"additional","affiliation":[{"name":"Pharmaceutical College Guangxi Medical University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117316"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2013.09.023"},{"issue":"1","key":"e_1_2_6_4_1","first-page":"88","article-title":"International Expert Consensus on Clinical Application of Traditional Chinese Medicine Formula Granules","volume":"6","author":"Xiong\u2010Zhi W. 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