{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:52:48Z","timestamp":1790751168320,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,20]],"date-time":"2025-04-20T00:00:00Z","timestamp":1745107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["NSTC\u2010112\u20102628\u2010B\u2010110\u2010005"],"award-info":[{"award-number":["NSTC\u2010112\u20102628\u2010B\u2010110\u2010005"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["NSTC\u2010113\u20102628\u2010B\u2010110\u2010001\u2010MY3"],"award-info":[{"award-number":["NSTC\u2010113\u20102628\u2010B\u2010110\u2010001\u2010MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytochemical Analysis"],"published-print":{"date-parts":[[2025,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n Introduction<\/jats:title>\n \n Callicarpa rubella<\/jats:italic>\n is a notable folk medicinal plant of the genus\n Callicarpa<\/jats:italic>\n . It is extensively ethnobotanically used for its traditional uses to cure rheumatism, inflammation, and pain in traditional Chinese medicinal systems.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n This study aimed to isolate unreported diterpenoids with anti\u2010inflammatory activities.<\/jats:p>\n <\/jats:sec>\n \n Material and Methods<\/jats:title>\n The planar structures of unreported compounds were characterized by interpreting 1D and 2D NMR spectra and HREIMS data. The absolute configurations were determined by comparing the experimental ECD spectra with calculated ECD ones. The potential anti\u2010inflammatory activities of all isolated compounds were assessed by testing their in\u00a0vitro inhibitory effects against superoxide anion generation and elastase release by human neutrophils in response to fMLP\/CB.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Investigation of chemical constituents from the leaves and twigs of\n \n C. rubella<\/jats:italic>\n <\/jats:styled-content>\n leads to the isolation of four unreported diterpenoids (\n 1<\/jats:bold>\n \u2013\n 4<\/jats:bold>\n ) along with 17 known diterpenoids (\n 5<\/jats:bold>\n \u2013\n 21<\/jats:bold>\n ). The results showed compounds\n 1<\/jats:bold>\n ,\n 3, 5<\/jats:bold>\n \u2013\n 7<\/jats:bold>\n ,\n 9<\/jats:bold>\n ,\n 12<\/jats:bold>\n ,\n 16<\/jats:bold>\n ,\n 18<\/jats:bold>\n , and\n 20<\/jats:bold>\n have potent inhibition against FMLP\/CB\u2010induced superoxide anion generation with IC\n 50<\/jats:sub>\n values range from 1.37\u2009\u00b1\u20090.09\u2009\u03bcM to 6.29\u2009\u00b1\u20091.14\u2009\u03bcM, while compounds\n 3<\/jats:bold>\n ,\n 6<\/jats:bold>\n ,\n 7<\/jats:bold>\n ,\n 9<\/jats:bold>\n ,\n 12<\/jats:bold>\n ,\n 16<\/jats:bold>\n ,\n 18<\/jats:bold>\n , and\n 20<\/jats:bold>\n showed potent inhibition of elastase release with IC\n 50<\/jats:sub>\n ranging from 1.47\u2009\u00b1\u20090.15\u2009\u03bcM to 5.79\u2009\u00b1\u20091.16\u2009\u03bcM.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The results obtained from the current study will enhance our understanding of diterpenoids from the\n Callicarpa<\/jats:italic>\n genus and support the identification of unreported diterpenoids with potential anti\u2010inflammatory agents.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/pca.3534","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T08:33:35Z","timestamp":1748334815000},"page":"1605-1613","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["New Diterpenoids With Anti\u2010Inflammatory Activity From\n Callicarpa rubella<\/i>\n Collected in Vietnam"],"prefix":"10.1002","volume":"36","author":[{"given":"Muhammad","family":"Ali","sequence":"first","affiliation":[{"name":"Department of Marine Biotechnology and Resources National Sun Yat\u2010sen University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010Rong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Marine Biotechnology and Resources National Sun Yat\u2010sen University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsong\u2010Long","family":"Hwang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Natural Products, College of Medicine Chang Gung University Taoyuan Taiwan"},{"name":"Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, and Graduate Institute of Health Industry Technology, College of Human Ecology Chang Gung University of Science and Technology Taoyuan Taiwan"},{"name":"Department of Anesthesiology Chang Gung Memorial Hospital Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsai\u2010Hui","family":"Duh","sequence":"additional","affiliation":[{"name":"Department of Medicinal and Applied Chemistry, College of Life Science Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Research Center for Precision Environmental Medicine Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limbadri","family":"Salendra","sequence":"additional","affiliation":[{"name":"Department of Marine Biotechnology and Resources National Sun Yat\u2010sen University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shah\u00a0Iram","family":"Niaz","sequence":"additional","affiliation":[{"name":"Institute of Chemical Sciences Gomal University Dera Ismail Khan KP Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei\u2010Wen","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Medical Education and Research Kaohsiung Veterans General Hospital Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6581-1320","authenticated-orcid":false,"given":"Yuan\u2010Bin","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Marine Biotechnology and Resources National Sun Yat\u2010sen University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3897\/phytokeys.62.7974"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ece3.9913"},{"key":"e_1_2_7_4_1","volume-title":"Flora of Vietnam, Volume 6\u2014Verbenaceae","author":"Phuong V. 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