{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T15:04:09Z","timestamp":1781535849855,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytochemical Analysis"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Panacis Quinquefolii Radix<\/jats:italic>\n                      , a valued herb in traditional Chinese medicine, is frequently prescribed for its immunomodulatory effects and its potential to improve cardiovascular function. Recently, there is an increasing amount of research on ginseng polysaccharides, due to their variety of pharmacological activities, including anti\u2010inflammatory, hepatoprotective, cardiovascular protective, and the improvement of intestinal function.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      This study investigates the efficacy of\n                      <jats:italic>Panacis Quinquefolii Radix<\/jats:italic>\n                      polysaccharides in alleviating cardiovascular diseases and to achieve the high\u2010value utilization of ginseng by\u2010products.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      A pectic polysaccharide named XYSJY2\u20102 was extracted with hot water from stems and leaves of\n                      <jats:italic>Panacis Quinquefolii Radix<\/jats:italic>\n                      and further isolated by a DEAE Sepharose Fast Flow column and a Sephacry S\u2010100 column. The structural characteristics of XYSJY2\u20102 was determined by monosaccharide composition, IR, NMR, and methylation analysis. The cardioprotective activity of this polysaccharide was evaluated in\u00a0vitro and in\u00a0vivo. With a relative molecular weight of 5.1\u2009kDa, XYSJY2\u20102 is a type I rhamnogalacturonan featuring a core backbone made up of alternately linked rhamnose and galacturonic acid.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>XYSJY2\u20102 effectively alleviated myocardial hypertrophy and remodeling induced by Ang II and TAC in\u00a0vivo and in\u00a0vitro, partly due to suppressing Nppa and Nppb expression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      A pectic polysaccharide from stems and leaves of\n                      <jats:italic>Panacis Quinquefolii Radix<\/jats:italic>\n                      has the potential to alleviate cardiovascular disease.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pca.3535","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T02:26:25Z","timestamp":1745375185000},"page":"2434-2444","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A Pectic Polysaccharide From Stems and Leaves of\n                    <i>Panacis Quinquefolii Radix<\/i>\n                    : Preparation, Structural Characteristic, and Inhibition of Cardiac Hypertrophy"],"prefix":"10.1002","volume":"36","author":[{"given":"Minghui","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Marine Pharmacology, College of Food Science and Technology Shanghai Ocean University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines China Pharmaceutical University  Nanjing 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