{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T08:15:16Z","timestamp":1780560916899,"version":"3.54.1"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21977120"],"award-info":[{"award-number":["21977120"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515110100"],"award-info":[{"award-number":["2022A1515110100"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytochemical Analysis"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      In this study, two new papulacandin analogs (\n                      <jats:bold>1<\/jats:bold>\n                      \u2013\n                      <jats:bold>2<\/jats:bold>\n                      ), together with 12 known compounds (\n                      <jats:bold>3<\/jats:bold>\n                      \u2013\n                      <jats:bold>14<\/jats:bold>\n                      ), were identified from the co\u2010culture of two endophytic fungi,\n                      <jats:italic>Pestalotiopsis<\/jats:italic>\n                      sp. J025 and\n                      <jats:italic>Nigrospora<\/jats:italic>\n                      sp. Wn\u20102\u20102, which were isolated from\n                      <jats:italic>Wikstroemia nutans<\/jats:italic>\n                      Champ. ex Benth.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study is to investigate the antifungal activity of papulacandins and other secondary metabolites from the co\u2010culture of two endophytic fungi.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Their chemical structures, including relative configurations, were elucidated using extensive spectroscopic analyses, including HRESIMS, 1D and 2D NMR, ECD calculations, and quantum mechanical\u2010NMR calculations, as well as comparison with reported analogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compound\n                      <jats:bold>3<\/jats:bold>\n                      demonstrated promising in\u00a0vitro antifungal activity against fluconazole\u2010resistant\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Candida albicans<\/jats:italic>\n                      <\/jats:styled-content>\n                      with a minimum inhibitory concentration in 50% isolates (MIC\n                      <jats:sub>50<\/jats:sub>\n                      ) of 0.57\u2009\u00b1\u20090.01\u2009\u03bcM.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      These findings demonstrate that the papulacandin family is a promising resource for the development of antifungal agents against invasive\n                      <jats:italic>Candida<\/jats:italic>\n                      infections.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pca.70024","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T13:35:45Z","timestamp":1756388145000},"page":"28-39","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Bioactive Spirocyclic\n                    <i>C<\/i>\n                    \u2010Arylglycosides From the Fungal\u2013Fungal Co\u2010Culture of\n                    <i>Pestalotiopsis<\/i>\n                    sp. and\n                    <i>Nigrospora<\/i>\n                    sp."],"prefix":"10.1002","volume":"37","author":[{"given":"Meifang","family":"Wu","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences (Shenzhen) Shenzhen Campus of Sun Yat\u2010Sen University  Shenzhen People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Jin","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences (Shenzhen) Shenzhen Campus of Sun Yat\u2010Sen University  Shenzhen People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences (Shenzhen) Shenzhen Campus of Sun Yat\u2010Sen University  Shenzhen People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqian","family":"Zeng","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences (Shenzhen) Shenzhen Campus of Sun Yat\u2010Sen University  Shenzhen People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Deng","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences (Shenzhen) Shenzhen Campus of Sun Yat\u2010Sen University  Shenzhen People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6891-2012","authenticated-orcid":false,"given":"Xiangdong","family":"Su","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences (Shenzhen) Shenzhen Campus of Sun Yat\u2010Sen University  Shenzhen People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9133-6439","authenticated-orcid":false,"given":"Yongbo","family":"Xue","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences (Shenzhen) Shenzhen Campus of Sun Yat\u2010Sen University  Shenzhen People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564\u2010022\u201001172\u20102"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aap7999"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00199"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/7081_2018_27"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9OB01598A"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.30.289"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3762\/bjoc.8.82"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00049\u2010010\u20100052\u20104"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2010.03.093"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c13101"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pca.3513"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/C2NP00073C"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41429\u2010018\u20100102\u20107"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010biochem\u2010081420\u2010102432"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1NP00070E"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.706044"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2021.780304"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.5b02396"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.104515"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202500701"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2008.04.086"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41429\u2010017\u20100015\u2010x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2020.104532"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja1096682"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2017.08.012"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf8033539"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2016.04.087"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.2174\/157018007781387773"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf062029d"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272\u2010001\u20101274\u20106"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.44.45"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.48.614"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.49.103"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.46.952"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.49.596"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1128\/aac.36.8.1648"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.48.608"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0040\u20104039(95)01751\u20103"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.001542"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2018.05.003"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201066824\u20101"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.3c00562"}],"updated-by":[{"DOI":"10.1002\/pca.70072","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000}}],"container-title":["Phytochemical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pca.70024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T08:59:55Z","timestamp":1767776395000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/pca.70024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,28]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/pca.70024"],"URL":"https:\/\/doi.org\/10.1002\/pca.70024","archive":["Portico"],"relation":{},"ISSN":["0958-0344","1099-1565"],"issn-type":[{"value":"0958-0344","type":"print"},{"value":"1099-1565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,28]]},"assertion":[{"value":"2025-05-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}