{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:05:45Z","timestamp":1790777145264,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2024ZYD0173"],"award-info":[{"award-number":["2024ZYD0173"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytochemical Analysis"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Notopterygium incisum<\/jats:italic>\n                      is a traditional Chinese and Tibetan medicinal herb widely used for treating colds, rheumatism, and musculoskeletal disorders.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      The aims of the study were to isolate sesquiterpenoids and polyacetylenes from\n                      <jats:italic>N. incisum<\/jats:italic>\n                      rhizomes and to evaluate their potential anti\u2013rheumatoid arthritis activity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Compounds were isolated using chromatographic techniques. Structures were elucidated by 1D\/2D NMR, UV, IR, and HRESIMS, and absolute configurations were assigned using TD\u2010DFT ECD calculations. Their anti\u2010RA activity was assessed by measuring pro\u2010inflammatory cytokine inhibition in TNF\u2010\u03b1\u2013induced MH7A cells. Some compounds were evaluated by molecular docking and molecular dynamics simulations to further explore possible molecular targets related to RA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010one compounds, including seven new ones and one newly identified natural product, were obtained. Several compounds showed significant inhibition of pro\u2010inflammatory cytokines in TNF\u2010\u03b1\u2013induced MH7A cells. Molecular docking also revealed varying degrees of binding affinity to RA\u2010relevant proteins, and dynamics simulations confirmed the stability of most selected complexes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      A series of sesquiterpenoids and polyacetylenes was isolated. Several compounds exhibited notable anti\u2010inflammatory activity, suggesting that these structural types may underlie the anti\u2010RA effects of\n                      <jats:italic>N. incisum<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pca.70037","type":"journal-article","created":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T07:44:18Z","timestamp":1762587858000},"page":"273-286","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Sesquiterpenoids and Polyacetylenes From\n                    <i>Notopterygium Incisum<\/i>\n                    With Anti\u2013Rheumatoid Arthritis Activity"],"prefix":"10.1002","volume":"37","author":[{"given":"Fan","family":"Wu","sequence":"first","affiliation":[{"name":"Chengdu Institute of Organic Chemistry Chinese Academy of Sciences  Chengdu People's Republic of China"},{"name":"Chengdu Institute of Biology Chinese Academy of Sciences  Chengdu People's Republic of China"},{"name":"University of Chinese Academy of Sciences  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Jian","family":"Gu","sequence":"additional","affiliation":[{"name":"Chengdu Institute of Biology Chinese Academy of Sciences  Chengdu People's Republic of China"},{"name":"University of Chinese Academy of Sciences  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Chen","sequence":"additional","affiliation":[{"name":"Chengdu Institute of Biology Chinese Academy of Sciences  Chengdu People's Republic of China"},{"name":"University of Chinese Academy of Sciences  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Xia","sequence":"additional","affiliation":[{"name":"Chengdu Institute of Biology Chinese Academy of Sciences  Chengdu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Chengdu Institute of Biology Chinese Academy of Sciences  Chengdu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Jun","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences Chengdu University of Traditional Chinese Medicine  Chengdu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Intelligent Medicine Chengdu University of Traditional Chinese Medicine  Chengdu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6400-6167","authenticated-orcid":false,"given":"Yu\u2010Cheng","family":"Gu","sequence":"additional","affiliation":[{"name":"Jealott's Hill International Research Centre Syngenta Ltd.  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