{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:10:42Z","timestamp":1787847042023,"version":"build-2784847793"},"reference-count":244,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytochemical Analysis"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Primary brain tumors are life\u2010threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of patients by causing serious side effects. Therefore, cutting\u2010edge therapies are required to alleviate patients' burden. Phytochemicals such as curcumin, quercetin, berberine, and resveratrol have been shown as potential therapeutic agents by demonstrating anticancer activity, including the inhibition of cell migration and proliferation, and the induction of apoptosis. This review summarizes the pharmacokinetic and cellular effects of phytochemicals that can be utilized in the treatment of medulloblastoma and glioblastoma by targeting cellular pathways associated with the progression of these diseases. Additionally, the synergistic relationships of these phytochemicals with traditional drugs and the emerging studies that utilize nanotechnology to ensure effective delivery of phytochemicals are covered in this review.<\/jats:p>","DOI":"10.1002\/pca.70067","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T11:10:19Z","timestamp":1776251419000},"page":"507-535","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Harnessing Phytochemicals for Brain Cancer Therapy: Insights Into Medulloblastoma and Glioblastoma Treatment"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4907-9082","authenticated-orcid":false,"given":"Ilkay\u00a0Irem","family":"Ozbek","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering Bogazici University  Bebek Istanbul Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3702-9706","authenticated-orcid":false,"given":"Mesra","family":"Aktas","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering Bogazici University  Bebek Istanbul Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6016-4651","authenticated-orcid":false,"given":"Hale","family":"Saybasili","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Bogazici University  Uskudar Istanbul Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3668-3467","authenticated-orcid":false,"given":"Kutlu\u00a0O.","family":"Ulgen","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering Bogazici University  Bebek Istanbul Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/jcrt.jcrt_1241_22"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2024.167647"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111928"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/02656736.2018.1430867"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010019\u20100063\u20106"},{"key":"e_1_2_14_7_1","unstructured":"S.Mahapatra andM. J.Amsbaugh. \u201cMedulloblastoma \u201d (2025)."},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010neuro\u2010070815\u2010013838"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.TIPS.2017.09.002"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S135561771300129X"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-100596-5.03055-9"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11671\u2010024\u201004172\u20109"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27113561"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432\u2010022\u201004387\u20102"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.5507\/bp.2014.032"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206948"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1081\/DMR\u2010200033473"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032657"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389200221666200103090757"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781003389781-9"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871520622666220324094033"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2022.0116"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/15593258221120485"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018877803319"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.ADDR.2016.09.004"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9030681"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12987\u2010024\u201000590\u20100"},{"key":"e_1_2_14_28_1","unstructured":"B. A.Elbakary \u201cThe Role of Phytochemicals in Modulating Breast Cancer Resistance Protein at the Blood\u2010Brain Barrier and the Blood\u2010Tumour Barrier \u201d (2021)."},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26199418"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12100948"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102407\u201010\u2010491"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.14264"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112040"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010017\u20103058\u20102"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2011.02.015"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471\u20104159.2007.04633.x"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S313961"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9656719"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871527315666160902144513"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16749"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.216955"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/3997190"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2016.01.019"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.963614"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2017.01.036"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349\u20107006.2009.01215.x"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210\u2010015\u20101191\u20105"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201010\u20104410"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1303726110"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.1.4.1"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom13030563"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22228"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24699"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5460"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells14191552"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033\u2010020\u201006087\u2010x"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0000000000000413"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12718"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2015.07.014"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41417\u2010024\u201000825\u20100"},{"key":"e_1_2_14_61_1","first-page":"1","article-title":"Chinese Journal of Natural Medicines Resveratrol: Botanical Origin","volume":"11","author":"Wu C. F.","year":"2013","journal-title":"Pharmacological Activity and Applications"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2015.4346"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432\u2010024\u201005625\u20105"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-03-0105"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2022.115409"},{"key":"e_1_2_14_66_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00541"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24087404"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.1000\u20109604.2013.10.01"},{"key":"e_1_2_14_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11655\u2010020\u20103190\u20108"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2020.109268"},{"key":"e_1_2_14_71_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods8060185"},{"key":"e_1_2_14_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2014.06.030"},{"issue":"3","key":"e_1_2_14_73_1","article-title":"TB\u20103 A Ginger extract Compound A Revealed Antitumor Activity Against Glioma. Neuro\u2010Oncology","volume":"4","author":"Inai K.","year":"2022","journal-title":"Advances"},{"key":"e_1_2_14_74_1","doi-asserted-by":"publisher","DOI":"10.9734\/ejmp\/2020\/v31i1030279"},{"key":"e_1_2_14_75_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19092832"},{"key":"e_1_2_14_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.23477"},{"key":"e_1_2_14_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495\u2010021\u201001684\u2010y"},{"key":"e_1_2_14_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hermed.2023.100798"},{"key":"e_1_2_14_79_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16233973"},{"key":"e_1_2_14_80_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535\u20107163.MCT\u201009\u20100407"},{"key":"e_1_2_14_81_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.558741"},{"key":"e_1_2_14_82_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046\u2010019\u20101173\u20104"},{"key":"e_1_2_14_83_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00025"},{"key":"e_1_2_14_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11655\u2010023\u20103752\u20107"},{"key":"e_1_2_14_85_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S539586"},{"key":"e_1_2_14_86_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1712599"},{"key":"e_1_2_14_87_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.52206"},{"key":"e_1_2_14_88_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935\u2010025\u201003636\u2010x"},{"key":"e_1_2_14_89_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28093795"},{"key":"e_1_2_14_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2025.111562"},{"key":"e_1_2_14_91_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28145578"},{"key":"e_1_2_14_92_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11396"},{"key":"e_1_2_14_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.03.132"},{"key":"e_1_2_14_94_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S279002"},{"key":"e_1_2_14_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2022.07.101"},{"key":"e_1_2_14_96_1","doi-asserted-by":"publisher","DOI":"10.1177\/15347354221130303"},{"key":"e_1_2_14_97_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26247659"},{"key":"e_1_2_14_98_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2010.29876"},{"key":"e_1_2_14_99_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10059\u2010011\u20100027\u20105"},{"key":"e_1_2_14_100_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871520618666180209151750"},{"key":"e_1_2_14_101_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27041299"},{"key":"e_1_2_14_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.217429"},{"key":"e_1_2_14_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2013.03.004"},{"key":"e_1_2_14_104_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222011201"},{"key":"e_1_2_14_105_1","doi-asserted-by":"publisher","DOI":"10.3171\/2016.8.JNS161197"},{"key":"e_1_2_14_106_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232214108"},{"key":"e_1_2_14_107_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0318185"},{"key":"e_1_2_14_108_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.23664"},{"key":"e_1_2_14_109_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201004\u20101827"},{"key":"e_1_2_14_110_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.936054"},{"key":"e_1_2_14_111_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010015\u20109320\u20101"},{"key":"e_1_2_14_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaim.2024.101013"},{"key":"e_1_2_14_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2009.02.002"},{"key":"e_1_2_14_114_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202101018"},{"key":"e_1_2_14_115_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants12233924"},{"key":"e_1_2_14_116_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40199\u2010019\u201000261\u20108"},{"key":"e_1_2_14_117_1","doi-asserted-by":"publisher","DOI":"10.3727\/096504018X15264647024196"},{"key":"e_1_2_14_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.119074"},{"key":"e_1_2_14_119_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29071682"},{"key":"e_1_2_14_120_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16122249"},{"key":"e_1_2_14_121_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2025.1646641"},{"key":"e_1_2_14_122_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11060824"},{"key":"e_1_2_14_123_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418\u2010020\u201001884\u20108"},{"key":"e_1_2_14_124_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032\u2010025\u201002984\u2010y"},{"key":"e_1_2_14_125_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222312654"},{"key":"e_1_2_14_126_1","doi-asserted-by":"publisher","DOI":"10.1177\/1934578X231224977"},{"key":"e_1_2_14_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.01.066"},{"key":"e_1_2_14_128_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102407\u201011\u2010144"},{"key":"e_1_2_14_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.04.069"},{"key":"e_1_2_14_130_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2014.3206"},{"key":"e_1_2_14_131_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.20604"},{"key":"e_1_2_14_132_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9324085"},{"key":"e_1_2_14_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9861(02)00302-8"},{"key":"e_1_2_14_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2022.122474"},{"key":"e_1_2_14_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.12.090"},{"key":"e_1_2_14_136_1","doi-asserted-by":"publisher","DOI":"10.3390\/life13020562"},{"key":"e_1_2_14_137_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13659\u2010015\u20100056\u20104"},{"key":"e_1_2_14_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2015.12.013"},{"key":"e_1_2_14_139_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.108.102616"},{"key":"e_1_2_14_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0304\u20103940(03)00894\u20102"},{"key":"e_1_2_14_141_1","doi-asserted-by":"publisher","DOI":"10.1593\/neo.08304"},{"key":"e_1_2_14_142_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060\u2010011\u20100645\u2010y"},{"issue":"6","key":"e_1_2_14_143_1","article-title":"Celastrol as a Potential Phytopharmaceutical for Medulloblastoma Therapy: Assessing Efficacy and Cardiotoxicity","volume":"1","author":"Imran A.","year":"2024","journal-title":"Bioscientist: The Salford Biomedicine Society Magazine"},{"key":"e_1_2_14_144_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010015\u20101596\u2010z"},{"key":"e_1_2_14_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401\u2010020\u201000514\u20102"},{"key":"e_1_2_14_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2003.08.025"},{"key":"e_1_2_14_147_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13568\u2010021\u201001281\u2010x"},{"key":"e_1_2_14_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2024.110216"},{"key":"e_1_2_14_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.174824"},{"key":"e_1_2_14_150_1","unstructured":"J.Parada\u2010Turska R.Paduch M.Majdan M.Kandefer\u2010Szersze\u00f1 andW.Rzeski. \u201cAntiproliferative Activity of Parthenolide Against Three Human Cancer Cell Lines and Human Umbilical Vein Endothelial Cells \u201d (2007)."},{"key":"e_1_2_14_151_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12102297"},{"key":"e_1_2_14_152_1","doi-asserted-by":"publisher","DOI":"10.1159\/000028993"},{"key":"e_1_2_14_153_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40360\u2010017\u20100160\u20107"},{"key":"e_1_2_14_154_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755\u20105949.2012.00319.x"},{"key":"e_1_2_14_155_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033\u2010008\u20109295\u20103"},{"key":"e_1_2_14_156_1","doi-asserted-by":"publisher","DOI":"10.3390\/life13020470"},{"key":"e_1_2_14_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173207"},{"key":"e_1_2_14_158_1","doi-asserted-by":"publisher","DOI":"10.3390\/pr10030448"},{"key":"e_1_2_14_159_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1431085"},{"key":"e_1_2_14_160_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13205\u2010023\u201003821\u20107"},{"key":"e_1_2_14_161_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12013\u2010014\u20100360\u20103"},{"key":"e_1_2_14_162_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010021\u201002674\u20106"},{"key":"e_1_2_14_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117807"},{"key":"e_1_2_14_164_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11133662"},{"key":"e_1_2_14_165_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.12298"},{"key":"e_1_2_14_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2012.08.002"},{"key":"e_1_2_14_167_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010018\u20104267\u2010z"},{"key":"e_1_2_14_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2023.166782"},{"key":"e_1_2_14_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2024.106313"},{"key":"e_1_2_14_170_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14122593"},{"key":"e_1_2_14_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109261"},{"key":"e_1_2_14_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2023.10.033"},{"key":"e_1_2_14_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2018.09.220"},{"key":"e_1_2_14_174_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2021.1885203"},{"key":"e_1_2_14_175_1","doi-asserted-by":"publisher","DOI":"10.4274\/forbes.galenos.2025.23865"},{"key":"e_1_2_14_176_1","doi-asserted-by":"publisher","DOI":"10.5812\/jjnpp.115464"},{"key":"e_1_2_14_177_1","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2020.1794100"},{"key":"e_1_2_14_178_1","doi-asserted-by":"publisher","DOI":"10.5582\/bst.2020.01005"},{"key":"e_1_2_14_179_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12010196"},{"key":"e_1_2_14_180_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S258584"},{"key":"e_1_2_14_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2013.07.013"},{"key":"e_1_2_14_182_1","volume-title":"Particle and Particle Systems Characterization","author":"Kawish S. M.","year":"2024"},{"key":"e_1_2_14_183_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms251910572"},{"key":"e_1_2_14_184_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2023.154427"},{"key":"e_1_2_14_185_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12017\u2010015\u20108372\u20108"},{"key":"e_1_2_14_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118027"},{"issue":"1","key":"e_1_2_14_187_1","first-page":"247","article-title":"Correlation Study of Inhibition of Gli1 and Foxm1 Expression by GANT61 and Apoptosis Induced by Daoy cells in Medulloblastoma","volume":"49","author":"Yang J.","year":"2022","journal-title":"Archives of Clinical Psychiatry"},{"key":"e_1_2_14_188_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10123216"},{"key":"e_1_2_14_189_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2025.116886"},{"key":"e_1_2_14_190_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.8b00551"},{"key":"e_1_2_14_191_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2018.1495239"},{"key":"e_1_2_14_192_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002800050534"},{"key":"e_1_2_14_193_1","doi-asserted-by":"publisher","DOI":"10.46871\/eams.2020.9"},{"key":"e_1_2_14_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2014.05.007"},{"key":"e_1_2_14_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-9556(25)07024-2"},{"issue":"13","key":"e_1_2_14_196_1","first-page":"71","article-title":"Drugs and the Liver","volume":"2","author":"Vaja R.","year":"2011","journal-title":"Pharmacology"},{"key":"e_1_2_14_197_1","unstructured":"K.Thummel \u201cFactors Influencing Drug Metabolism \u201dhttp:\/\/www.imm.ki.se\/CYPalleles."},{"key":"e_1_2_14_198_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr195"},{"key":"e_1_2_14_199_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22020729"},{"key":"e_1_2_14_200_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7980"},{"key":"e_1_2_14_201_1","doi-asserted-by":"crossref","unstructured":"A. J.Janss C.Levow E. J.Bernhard et\u00a0al. \u201cCaffeine and Staurosporine Enhance the Cytotoxicity of Cisplatin and Camptothecin in Human Brain Tumor Cell Lines \u201d (1998).","DOI":"10.1006\/excr.1998.4122"},{"key":"e_1_2_14_202_1","doi-asserted-by":"publisher","DOI":"10.3109\/10717544.2014.923956"},{"key":"e_1_2_14_203_1","doi-asserted-by":"crossref","unstructured":"K.Vimala andS.Kannan. \u201cPhyto\u2010Drug Conjugated Nanomaterials Enhance Apoptotic Activity in Cancer \u201d (2021) 275\u2013305.https:\/\/doi.org\/10.1016\/bs.apcsb.2020.12.003.","DOI":"10.1016\/bs.apcsb.2020.12.003"},{"issue":"4","key":"e_1_2_14_204_1","first-page":"1411","article-title":"Effects of Quercetin on the Pharmacokinetics of Etoposide after Oral or Intravenous Administration of Etoposide in Rats","volume":"29","author":"Li X.","year":"2009","journal-title":"Anticancer Research"},{"key":"e_1_2_14_205_1","article-title":"\ud56d\uc0b0\ud654\uc81c\uc778 \uc544\ud53c\uc81c\ub2cc\uc774 \uc5d0\ud1a0\ud3ec\uc2dc\ub4dc\uc758 \uc0dd\uccb4\uc774\uc6a9\ub960 \ubc0f \uc57d\ub3d9\ud559\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5 Effects of Apigenin, an Antioxidant, on the Bioavailability and Pharmacokinetics of Etoposide","volume":"21","author":"Lim T. H.","year":"2011","journal-title":"Korean Journal of Clinical Pharmacy"},{"key":"e_1_2_14_206_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2017.1251903"},{"key":"e_1_2_14_207_1","volume-title":"Some Plant Species Used In The Treatment of Rheumatic Diseases Among The Public In Turkey","author":"\u00d6zp\u0131nar H.","year":"2023"},{"key":"e_1_2_14_208_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph14101036"},{"key":"e_1_2_14_209_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031\u2010023\u201002174\u20103"},{"key":"e_1_2_14_210_1","doi-asserted-by":"publisher","DOI":"10.1515\/tjb\u20102023\u20100150"},{"key":"e_1_2_14_211_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1695200"},{"key":"e_1_2_14_212_1","unstructured":"MAzhari Herli AEka Putra andABakhtiar \u201cMolecular Docking Studies of Flavonoid Bioactive Compound Against RNA Polymerase Mycobacterium tuberculosis \u201d (2016) http:\/\/pubchem.ncbi.nlm.nih.gov\/."},{"key":"e_1_2_14_213_1","doi-asserted-by":"publisher","DOI":"10.3727\/096504015X14298122915583"},{"key":"e_1_2_14_214_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011\u2010018\u20100348\u20106"},{"key":"e_1_2_14_215_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.762654"},{"key":"e_1_2_14_216_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2003.11.023"},{"key":"e_1_2_14_217_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2015.01.003"},{"key":"e_1_2_14_218_1","first-page":"69","volume-title":"Advances in Molecular Toxicology","author":"Bansal M.","year":"2018"},{"key":"e_1_2_14_219_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.comptc.2020.112850"},{"key":"e_1_2_14_220_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114507824093"},{"key":"e_1_2_14_221_1","doi-asserted-by":"publisher","DOI":"10.1039\/c5ra04303d"},{"key":"e_1_2_14_222_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2022.e12028"},{"key":"e_1_2_14_223_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010024\u201003917\u2010y"},{"key":"e_1_2_14_224_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jafr.2025.101661"},{"key":"e_1_2_14_225_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16091169"},{"key":"e_1_2_14_226_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15030963"},{"key":"e_1_2_14_227_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210\u2010025\u201003934\u20101"},{"key":"e_1_2_14_228_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14081643"},{"key":"e_1_2_14_229_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420\u2010018\u20100103\u20100"},{"key":"e_1_2_14_230_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14246222"},{"key":"e_1_2_14_231_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.2436"},{"key":"e_1_2_14_232_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.03.006"},{"key":"e_1_2_14_233_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.113528"},{"key":"e_1_2_14_234_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15020448"},{"key":"e_1_2_14_235_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.120435"},{"key":"e_1_2_14_236_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2018.11.020"},{"key":"e_1_2_14_237_1","doi-asserted-by":"publisher","DOI":"10.26599\/NR.2025.94908011"},{"key":"e_1_2_14_238_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2024.127712"},{"key":"e_1_2_14_239_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpta.2021.100106"},{"key":"e_1_2_14_240_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01977618"},{"key":"e_1_2_14_241_1","doi-asserted-by":"publisher","DOI":"10.3390\/cimb46120859"},{"key":"e_1_2_14_242_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1121950"},{"key":"e_1_2_14_243_1","doi-asserted-by":"publisher","DOI":"10.5530\/fpi.2.1.1"},{"key":"e_1_2_14_244_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc\u20102023\u2010006880"},{"key":"e_1_2_14_245_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.1c06569"}],"container-title":["Phytochemical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pca.70067","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pca.70067","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pca.70067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T03:01:19Z","timestamp":1780455679000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/pca.70067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,15]]},"references-count":244,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/pca.70067"],"URL":"https:\/\/doi.org\/10.1002\/pca.70067","archive":["Portico"],"relation":{},"ISSN":["0958-0344","1099-1565"],"issn-type":[{"value":"0958-0344","type":"print"},{"value":"1099-1565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,15]]},"assertion":[{"value":"2025-08-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}