{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:23:51Z","timestamp":1783013031721,"version":"3.54.6"},"reference-count":116,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004621","name":"Kerman University of Medical Sciences","doi-asserted-by":"publisher","award":["404000546"],"award-info":[{"award-number":["404000546"]}],"id":[{"id":"10.13039\/501100004621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytochemical Analysis"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Curcumin (CUR), an active secondary metabolite of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Curcuma longa<\/jats:italic>\n                      <\/jats:styled-content>\n                      , is known for its therapeutic effects in diverse neoplastic and nonneoplastic conditions. Here, we systematically reviewed relevant literature to explore the efficacy and cytotoxicity of CUR and its derivatives in treating chronic myeloid leukemia (CML) in preclinical and clinical settings.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We followed the PRISMA guideline to conduct a systematic literature search in PubMed, Web of Science, Scopus, and Embase on March 8, 2025, using relevant keywords, including chronic myeloid leukemia, CUR, and CUR derivatives. A manual search on Google Scholar was also performed to ensure comprehensive literature coverage. Duplicates were removed, and papers were evaluated for eligibility through a two\u2010phase screening process. Data were then extracted and qualitatively analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 728 publications were identified. After removing duplicates and irrelevant literature, the abstracts of 318 papers were assessed for eligibility. Finally, 64 studies (55 retrieved via database search and nine through manual search) were analyzed. Preclinical evidence demonstrated the antiproliferative and proapoptotic effects of CUR and its derivatives, alone or in combination with traditional therapies, against CML cells and models. Also, a single clinical study supported the adjunctive therapeutic effect of CUR in combination with imatinib.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Preclinical evidence supports the potential role of CUR and its derivatives, adjuvant or stand\u2010alone therapeutic agents, for CML management. More comprehensive clinical trials are warranted to validate these findings, optimize CUR formulations and dosing strategies, and maximize their clinical benefits.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pca.70074","type":"journal-article","created":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T01:05:33Z","timestamp":1777683933000},"page":"716-745","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preclinical and Clinical Evidence on the Efficacy and Cytotoxicity of Curcumin and Curcumin Derivatives in Chronic Myeloid Leukemia: A Systematic Review"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3574-2948","authenticated-orcid":false,"given":"Seyed\u00a0Mohammad","family":"Hosseini","sequence":"first","affiliation":[{"name":"Department of Hematology and Medical Laboratory Sciences, Faculty of Allied Medicine Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2614-8380","authenticated-orcid":false,"given":"Fatemeh","family":"Peymaninezhad","sequence":"additional","affiliation":[{"name":"Student Research Committee Kerman University of Medical Sciences  Kerman Iran"},{"name":"Stem Cells and Regenerative Medicine Innovation Center Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2168-0520","authenticated-orcid":false,"given":"Fatemeh","family":"Khademi","sequence":"additional","affiliation":[{"name":"Student Research Committee Kerman University of Medical Sciences  Kerman Iran"},{"name":"Stem Cells and Regenerative Medicine Innovation Center Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9618-5609","authenticated-orcid":false,"given":"Alireza","family":"Khiabani","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Laboratory Sciences, Faculty of Allied Medicine Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7686-0822","authenticated-orcid":false,"given":"Alireza","family":"Khanahmad","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Laboratory Sciences, Faculty of Allied Medicine Kerman University of Medical Sciences  Kerman Iran"},{"name":"Student Research Committee Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0276-6881","authenticated-orcid":false,"given":"Alireza","family":"Farsinejad","sequence":"additional","affiliation":[{"name":"Stem Cells and Regenerative Medicine Innovation Center Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4872-1352","authenticated-orcid":false,"given":"Ali","family":"Bazi","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Laboratory Sciences, Faculty of Allied Medicine Kerman University of Medical Sciences  Kerman Iran"},{"name":"Faculty of Allied Medical Sciences Zabol University of Medical Sciences  Zabol Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,1]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2024.155161"},{"issue":"1","key":"e_1_2_10_3_1","first-page":"63","article-title":"Role of Oxidative Stress in Modulating Unfolded Protein Response Activity in Chronic Myeloid Leukemia Cell Line","volume":"20","author":"Bazi A.","year":"2016","journal-title":"Iranian Biomedical Journal"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/JBM.S382090"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S314343"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V82.12.3524.3524"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.5.1330.1330"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.8.3091.bloodjournal8883091"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-08-3097"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-023-00823-9"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2021.100825"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phyplu.2022.100396"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1051998"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/4418466"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01614"},{"issue":"9","key":"e_1_2_10_16_1","article-title":"The Role of Curcumin in Cancer Treatment","volume":"9","author":"Zoi V.","year":"2021","journal-title":"Biomedicine"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules20022728"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/1078155211416530"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2013.180"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2024.106442"},{"issue":"2","key":"e_1_2_10_21_1","first-page":"141","article-title":"Evaluation of the Effect of Curcumin and Imatinib on BCR\u2010ABL Expression Gene in Chronic Human k562 Cells","volume":"9","author":"Virany Z. G.","year":"2022","journal-title":"International Journal of Medical the Laboratory"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.31661\/gmj.v7i0.921"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43440-020-00073-7"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo13010058"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2018.1380208"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384047.2016.1276129"},{"issue":"1","key":"e_1_2_10_27_1","first-page":"83","article-title":"Curcumin Increases the Sensitivity of K562\/DOX Cells to Doxorubicin by Targeting S100 Calcium\u2010Binding Protein A8 and P\u2010Glycoprotein","volume":"19","author":"Yang L.","year":"2020","journal-title":"Oncology Letters"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2009.01.031"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10876-024-02607-y"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.04.043"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02977473"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2016.01.012"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp100455h"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2010.07.063"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.70313"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1615\/JEnvironPatholToxicolOncol.2014010913"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.1992.12098244"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/10286020903264077"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7254.2006.00471.x"},{"issue":"11","key":"e_1_2_10_40_1","first-page":"1155","article-title":"Inhibitory Effect of Curcumin on Proliferation of K562 Cells Involves Down\u2010Regulation of p210 (Bcr\/abl) Initiated Ras Signal Transduction Pathway","volume":"24","author":"Wu L.\u2010X.","year":"2003","journal-title":"Acta Pharmacologica Sinica"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7254.2006.00326.x"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4204"},{"issue":"5","key":"e_1_2_10_43_1","first-page":"S1193","article-title":"Combinatorial Effect of Curcumin and Tumor Necrosis Factor\u2010\u0391\u2010Related Apoptosis\u2010Inducing Ligand (TRAIL) in Induction of Apoptosis via Inhibition of Nuclear Factor Kappa Activity and Enhancement of Caspase\u20103 Activity in Chronic Myeloid Cells: An: In\u2010Vitro: Study","volume":"14","author":"Iqbal B.","year":"2018","journal-title":"Journal of Cancer Research and Therapeutics"},{"issue":"5","key":"e_1_2_10_44_1","first-page":"6777","article-title":"Curcumin Differentially Affects Cell Cycle and Cell Death in Acute and Chronic Myeloid Leukemia Cells","volume":"15","author":"Mart\u00ednez\u2010Castillo M.","year":"2018","journal-title":"Oncology Letters"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2015.05.057"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2012.680064"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02973907"},{"issue":"4","key":"e_1_2_10_48_1","article-title":"Antiproliferative and Apoptotic Effect of Curcumin and TRAIL (TNF Related Apoptosis Inducing Ligand) in Chronic Myeloid Leukaemic Cells","volume":"10","author":"Iqbal B.","year":"2016","journal-title":"Journal of Clinical and Diagnostic Research: JCDR"},{"key":"e_1_2_10_49_1","first-page":"1","article-title":"SWATH\u2010MS Based Quantitative Proteomics Analysis Reveals That Curcumin Alters the Metabolic Enzyme Profile of CML Cells by Affecting the Activity of miR\u201022\/IPO7\/HIF\u20101\u03b1 Axis","volume":"37","author":"Monteleone F.","year":"2018","journal-title":"Experimental & Clinical Cancer Research"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-05-0172"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2013.776167"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.22169"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2006.07.029"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.13659"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.110.168344"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02819533"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-018-9324-y"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgt070"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.04731.x"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1397.041"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2018.07.031"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8483"},{"issue":"1","key":"e_1_2_10_63_1","first-page":"18","article-title":"The Involvement of Canonical NF\u03baB Pathway in Megakaryocyte Differentiation Induction by Nanocurcumin","volume":"17","author":"Farsani S. S. M.","year":"2023","journal-title":"International Journal of Hematology\u2010Oncology and Stem Cell Research"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.22207\/JPAM.12.2.04"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-36888-x"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2020.1767167"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-20179-6"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0165971"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112331"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-3317"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22040633"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032356"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2017.160"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-020-00652-4"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2016.11.023"},{"issue":"2","key":"e_1_2_10_76_1","first-page":"225","article-title":"Bioinformatic and Molecular Interaction Studies Uncover That CCA\u20101.1 and PGV\u20101 Differentially Target Mitotic Regulatory Protein and Have a Synergistic Effect Against Leukemia Cells","volume":"33","author":"Meiyanto E.","year":"2022","journal-title":"Indonesian Journal of Pharmacy"},{"issue":"1","key":"e_1_2_10_77_1","first-page":"96","article-title":"Different Mitotic Arrest Targets of Chemoprevention Curcumin Analog 1.1 (CCA\u20101.1) and Pentagamavunone\u20101 (PGV\u20101) in Leukemic K\u2010562 Cells","volume":"31","author":"Jenie R. I.","year":"2024","journal-title":"Pharmaceutical Sciences"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24224067"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-51244-3"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4RA03655G"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/524161"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871520616666160201151206"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15068"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2017.12.011"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.3390\/life12091427"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-021-02240-z"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.00514"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7254.2005.00081.x"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057709"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.14712\/fb2010056050195"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570161116666180209113014"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.06.119"},{"issue":"6","key":"e_1_2_10_93_1","first-page":"1557","article-title":"Curcumin Inhibits Hypoxia\u2010Induced Angiogenesis via Down\u2010Regulation of HIF\u20101","volume":"15","author":"Bae M. K.","year":"2006","journal-title":"Oncology Reports"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-3072"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6703"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.26"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7RA02994B"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00877"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1007\/112_2016_3"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M410670200"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7734"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2011.04.002"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2010.11"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-09-0377"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2014.15.16.6893"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2008.06.031"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.6.2.3577"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2005.04.043"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1515\/biol-2022-0618"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21300"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-12-564"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.7.3863"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2015.1085581"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-0024"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2015.09.020"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.4060"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-014-3198-2"}],"container-title":["Phytochemical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pca.70074","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pca.70074","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pca.70074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T16:58:29Z","timestamp":1783011509000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/pca.70074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,1]]},"references-count":116,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/pca.70074"],"URL":"https:\/\/doi.org\/10.1002\/pca.70074","archive":["Portico"],"relation":{},"ISSN":["0958-0344","1099-1565"],"issn-type":[{"value":"0958-0344","type":"print"},{"value":"1099-1565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,1]]},"assertion":[{"value":"2025-12-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}