{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:23:53Z","timestamp":1783013033910,"version":"3.54.6"},"reference-count":65,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82474217"],"award-info":[{"award-number":["82474217"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytochemical Analysis"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Bupleuri Radix (BR) and Rhei Radix et Rhizoma (RR) are commonly used in combination in traditional Chinese medicine, yet the chemical basis of their compatibility and the liver\u2010exposed constituents after oral administration remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To systematically characterize the chemical constituents of the Bupleuri Radix\u2010Rhei Radix et Rhizoma (BR\u2010RR) aqueous extract and to investigate the exposed prototype components and metabolites in mouse liver after oral administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>UPLC\u2010Q\u2010Orbitrap\u2010MS was employed to comprehensively analyze the chemical constituents of the BR\u2010RR aqueous extract and the liver\u2010exposed components in mice after gavage administration. Compound identification was performed by integrating retention times, accurate molecular weights, and multistage MS fragmentation data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 109 compounds were tentatively identified in the BR\u2010RR aqueous extract, including anthraquinones, saponins, flavonoids, phenols, and organic acids. In mouse liver samples, 25 prototype components and 21 metabolites were tentatively characterized after oral administration, among which anthraquinones were the predominant chemical class. These findings revealed the major in\u00a0vivo exposed constituents and metabolic characteristics of the BR\u2010RR extract in the liver.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study systematically characterized the chemical constituents of the BR\u2010RR aqueous extract and elucidated its liver exposure profile in mice. The findings provide an overall view of the in\u00a0vivo exposure and metabolic characteristics of the extract and offer useful reference information for quality evaluation and further investigation of its material basis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pca.70076","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T08:16:13Z","timestamp":1778141773000},"page":"761-791","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigation of the Chemical Constituents and Hepatic\u2010Exposed Components of the Bupleuri Radix\u2013Rhei Radix et Rhizoma Herbal Pair Based on UPLC\u2010Q\u2010Orbitrap\u2010MS Analysis"],"prefix":"10.1002","volume":"37","author":[{"given":"Xinyu","family":"Dai","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Materia Medica Tianjin University of Traditional Chinese Medicine  Tianjin 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