{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:08:11Z","timestamp":1790140091601,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007162","name":"Guangdong Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["2025A0505010017"],"award-info":[{"award-number":["2025A0505010017"]}],"id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytochemical Analysis"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Murrayae Folium et Cacumen (MFC) is a multioriginated Chinese herbal medicine (CHM) derived from the plants of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Murraya exotica<\/jats:italic>\n                      <\/jats:styled-content>\n                      L. (ME) and\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>M. paniculata<\/jats:italic>\n                      <\/jats:styled-content>\n                      (L.) Jack (MP). Although the two plants are both used as MFC in clinics, comparative investigations between them in chemistry and pharmacology are not reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aims to provide systematic comparative investigations on the chemical and bioactive (anti\u2010inflammatory\/antioxidant) profiles between ME and MP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The chemical compositions of ME and MP were characterized by ultra\u2010performance liquid chromatography (UPLC) and comparatively analyzed with chromatographic fingerprint analysis, hierarchical clustering analysis (HCA), and principal component analysis (PCA). The distribution of species\u2010specific components in ME and MP was quantitatively determined. Moreover, the bioactivities of ME and MP were compared in LPS\u2010stimulated RAW264.7 macrophages, focusing on their modulation of key inflammatory mediators, oxidative stress markers, and the underlying NF\u2010\u03baB\/MAPKs signaling pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>ME and MP presented significant differences in chemistry and could be well distinguished from each other by HCA and PCA based on the UPLC fingerprint chromatograms. Coumarins (meranzin hydrate and hainanmurpanin) and polymethoxylated flavonoids (luteolin tetramethylether, 5,7,3\u2032,4\u2032,5\u2032\u2010pentamethoxyflavone, 3\u2032,4\u2032,5,5\u2032,6,7\u2010hexamethoxyflavone, and 5\u2010demethylnobiletin) were observed to accumulate specifically in ME and MP, respectively. Moreover, ME and MP exhibited comparable activities in ameliorating inflammatory response and oxidative stress in LPS\u2010induced RAW264.7 cells through suppressing the activation of NF\u2010\u03baB and MAPKs signaling pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ME and MP presented similarity in potency against inflammation and oxidation, but with differences in pharmacological mechanisms due to their difference in chemistry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pca.70090","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:56:13Z","timestamp":1790139373000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Comprehension on the Multioriginated Chinese Herb Murrayae Folium et Cacumen: From Chemical Compositions to Pharmacological Activities"],"prefix":"10.1002","author":[{"given":"Guanding","family":"Zhao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Mechanism and Quality of Chinese Medicine University of Macau  Macao SAR China"},{"name":"Institute of Chinese Medical Sciences University of Macau  Macao SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoping","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Mechanism and Quality of Chinese Medicine University of Macau  Macao SAR China"},{"name":"Institute of Chinese Medical Sciences University of Macau  Macao SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junming","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Mechanism and Quality of Chinese Medicine University of Macau  Macao SAR China"},{"name":"Institute of Chinese Medical Sciences University of Macau  Macao SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6472-9544","authenticated-orcid":false,"given":"Mingming","family":"Zhao","sequence":"additional","affiliation":[{"name":"Institute of Chinese Medical Sciences University of Macau  Macao SAR China"},{"name":"Department of Biomolecular Sciences, School of Pharmacy University of Mississippi  Oxford Mississippi USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiansong","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangdong Province Key Laboratory for Core Technology of Chemical Raw Materials and Pharmaceutical Formulations Guangzhou Baiyunshan Pharmaceutical Holding Co., Ltd.  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Xie","sequence":"additional","affiliation":[{"name":"China Resources Sanjiu Medical &amp; Pharmaceutical Co., Ltd.  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9466-6721","authenticated-orcid":false,"given":"Hua","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Mechanism and Quality of Chinese Medicine University of Macau  Macao SAR China"},{"name":"Institute of Chinese Medical Sciences University of Macau  Macao SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.112530"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2022"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pca.70004"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pca.70039"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1337161"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114567"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2015.1089294"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pca.70048"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1875\u20105364(26)61179\u2010X"},{"issue":"10","key":"e_1_2_10_11_1","first-page":"1473","article-title":"Comparative Analysis of the Essential Oil Composition of Murraya paniculata and M. exotica","volume":"8","author":"Lv H. 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