{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:41:01Z","timestamp":1792370461855,"version":"4.4.0"},"reference-count":58,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytochemical Analysis"],"abstract":"ABSTRACT<\/jats:title>\n \n Introduction<\/jats:title>\n Colorectal cancer (CRC) remains one of the leading causes of cancer\u2010related mortality worldwide. Combination therapies, which integrate traditional Chinese medicine (TCM) with conventional chemotherapeutic agents, offer a promising new strategy for the management of CRC.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n This study aimed to investigate the potential of\n \n Aloe vera<\/jats:italic>\n <\/jats:styled-content>\n (L.) Burm.f. (\n \n A.\u2009vera<\/jats:italic>\n <\/jats:styled-content>\n ) as an adjuvant to hydroxycamptothecin (HCPT) for CRC treatment and to explore the underlying mechanisms, specifically focusing on nucleotide metabolism, as perturbations in intracellular nucleotide pools are closely linked to various human pathologies.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The aqueous extract of\n \n A.\u2009vera<\/jats:italic>\n <\/jats:styled-content>\n adjuvantly ameliorated the progression of colon carcinogenesis was investigated in\n Apc<\/jats:italic>\n Min\/+<\/jats:sup>\n mouse model. For the underlying mechanism studies, cytotoxicity assessment, DNA damage, cell cycle, RNA and DNA synthesis analysis, endogenous nucleotides determination, and Western blot were performed in HCT 116 cells.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Major constituents of\n \n A.\u2009vera<\/jats:italic>\n <\/jats:styled-content>\n , including aloin A, aloin B, aloesin, aloenin, and aloe\u2010emodin, were quantified and found to meet Chinese Pharmacopoeia standards.\n \n A.\u2009vera<\/jats:italic>\n <\/jats:styled-content>\n synergistically enhanced the anticancer activity of HCPT. This effect was mediated by exacerbated DNA damage, imbalanced purine\/pyrimidine metabolism, and inhibition of the Wnt\/\u03b2\u2010catenin signaling pathway.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This study provided preliminary evidence that\n \n A.\u2009vera<\/jats:italic>\n <\/jats:styled-content>\n could be developed as an adjuvant therapy for CRC, contributing to its further clinical application in this field.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/pca.70096","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:05:51Z","timestamp":1792368351000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["\n Aloe vera<\/i>\n <\/scp>\n Enhanced Hydroxycamptothecin\u2010Mediated Antitumor Activity in Colorectal Carcinoma Based on the Targeted Regulation of Nucleotide Metabolism"],"prefix":"10.1002","author":[{"given":"Cai\u2010Yun","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Mechanism and Quality of Chinese Medicine & Faculty of Chinese Medicine Macau University of Science and Technology Macau China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Mechanism and Quality of Chinese Medicine & Faculty of Chinese Medicine Macau University of Science and Technology Macau China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1620-6332","authenticated-orcid":false,"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Mechanism and Quality of Chinese Medicine, Macau Institute for Applied Research in Medicine and Health Macau University of Science and Technology Macau China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7956-2481","authenticated-orcid":false,"given":"Zhi\u2010Hong","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Mechanism and Quality of Chinese Medicine, Macau Institute for Applied Research in Medicine and Health Macau University of Science and Technology Macau China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,18]]},"reference":[{"issue":"3","key":"e_1_2_8_2_1","first-page":"229","article-title":"Global Cancer Statistics 2022: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"74","author":"Bray F.","year":"2024","journal-title":"CA: A Cancer Journal for Clinicians"},{"issue":"6","key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1007\/s10552-013-0201-5","article-title":"Meta\u2010Analyses of Colorectal Cancer Risk Factors","volume":"24","author":"Johnson C. 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