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Such hazardous compounds can be present only in very low concentrations in phyto\u2010pharmaceutical preparations and hence, for the purposes of drug safety, techniques must be available for the identi\ufb01cation and quanti\ufb01cation of these allergens at extremely low levels in re\ufb01ned manufactured materials. GC\u2010MS analysis of samples collected at various stages during the production process of a standardised extract of <jats:italic>G. biloba<\/jats:italic> (EGb 761) demonstrated that all alkylphenols present in the primary acetone extracts were removed in parallel with the same ef\ufb01ciency irrespective of their aromatic substitution pattern. Furthermore, in the \ufb01nal product the content of urushiols was generally below the detection limit of 0.03 ppm. Therefore, it is concluded that demonstrating the absence of the predominant, and easily quanti\ufb01able, ginkgolic acids provides a reliable means for the control of pharmaceutical quality of the \ufb01nal product. 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