{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:55:04Z","timestamp":1791269704064,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,1,23]],"date-time":"2004-01-23T00:00:00Z","timestamp":1074816000000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytochemical Analysis"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The possibilities and limitations of supercritical \ufb02uid extraction of natural products of low, medium and high polarity under very high pressure and with polar modi\ufb01ers has been investigated. The medicinal herbs marigold (<jats:italic>Calendula of\ufb01cinalis<\/jats:italic>), hawthorn (<jats:italic>Crataegus<\/jats:italic> sp.) and chamomile (<jats:italic>Matricaria recutita<\/jats:italic>) were used as models in this study. Extraction pro\ufb01les and the spectra of extractable metabolites were recorded following extraction with mixtures of carbon dioxide:ethanol of varying proportions (0\u201320% ethanol) and at various pressures in the range 300\u2013689 bar. Components were identi\ufb01ed by HPLC\u2010PAD\u2010MS or GC\u2010MS and quanti\ufb01ed by HPLC or GC as appropriate. Extraction yields under the varying conditions depended to a large extent on the pro\ufb01les of secondary metabolites present in the three drugs. Whereas the extractability of lipophilic compounds increased substantially at pressures above 300 bar, the yields of polyphenolic and glycosidic compounds remained low even at 689 bar and with 20% modi\ufb01er in the extraction \ufb02uid. Copyright \u00a9 2004 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/pca.743","type":"journal-article","created":{"date-parts":[[2004,1,26]],"date-time":"2004-01-26T03:09:06Z","timestamp":1075086546000},"page":"46-54","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":106,"title":["Supercritical carbon dioxide extraction of selected medicinal plants\u2014effects of high pressure and added ethanol on yield of extracted substances"],"prefix":"10.1002","volume":"15","author":[{"given":"M.","family":"Hamburger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Baumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Adler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,1,23]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/np0004395"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(99)00071-0"},{"key":"e_1_2_1_4_1","unstructured":"BeuscherN WilligmannI.1993. Pharmaceutically active composition extracted fromTanacetum parthenium process for its extraction and pharmaceutical composition containing same. EP 0553658."},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-2670(98)00060-9"},{"key":"e_1_2_1_6_1","first-page":"95","article-title":"L'extraction en phase supercritique de substances d'origine v\u00e9g\u00e9tale","volume":"23","author":"Castioni P","year":"1995","journal-title":"Analusis"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-15805"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-20252"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/ie00061a011"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac00058a026"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026095608691"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0367-326X(03)00051-0"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhrc.1240161109"},{"key":"e_1_2_1_14_1","volume-title":"Die Ringelblume\u2014Botanik, Chemie, Pharmakologie, Toxikologie, Pharmazie und therapeutische Verwendung.","author":"Isaac O","year":"1992"},{"key":"e_1_2_1_15_1","first-page":"907","article-title":"Pharmaceutical applications of supercritical carbon dioxide","volume":"56","author":"Kaiser CS","year":"2001","journal-title":"Pharmazie"},{"key":"e_1_2_1_16_1","volume-title":"Der Weissdorn\u2014Botanik, Inhaltsstoffe, Qualit\u00e4tskontrolle, Pharmakologie, Toxikologie und Klinik","author":"Kaul R","year":"1998"},{"key":"e_1_2_1_17_1","volume-title":"Technologie pflanzlicher Arzneizubereitungen","author":"List PH","year":"1984"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1565(199601)7:1<1::AID-PCA275>3.0.CO;2-U"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/np960432g"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1565(199709\/10)8:5<257::AID-PCA362>3.0.CO;2-R"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf9912506"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf990019p"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf990957p"},{"key":"e_1_2_1_24_1","volume-title":"Abstracts of the 46th Annual Congress of the Society for Medicinal Plant Research","author":"Reh K","year":"1998"},{"key":"e_1_2_1_25_1","volume-title":"Die Kamille\u2014Handbuch f\u00fcr \u00c4rzte, Apotheker und andere Naturwissenschaftler.","author":"Schilcher H","year":"1987"},{"key":"e_1_2_1_26_1","first-page":"509","volume-title":"Proceedings of the 5th Meeting on Supercritical Fluids\u2014Materials and Natural Products Processing","author":"Steiner R","year":"1998"},{"key":"e_1_2_1_27_1","unstructured":"SteinerR HaukA TratzW.1999. Method for producing medicinal plant extracts. WO 99\/18984."},{"key":"e_1_2_1_28_1","volume-title":"Supercritical Fluid Extraction","author":"Taylor LT","year":"1996"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002160050851"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf00059a006"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/pca.582"}],"container-title":["Phytochemical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpca.743","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pca.743","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T09:40:08Z","timestamp":1761039608000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/pca.743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["10.1002\/pca.743"],"URL":"https:\/\/doi.org\/10.1002\/pca.743","archive":["Portico"],"relation":{},"ISSN":["0958-0344","1099-1565"],"issn-type":[{"value":"0958-0344","type":"print"},{"value":"1099-1565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,1]]},"assertion":[{"value":"2002-11-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2003-09-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2004-01-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}