{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:07:46Z","timestamp":1790680066742,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,6,29]],"date-time":"2004-06-29T00:00:00Z","timestamp":1088467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytochemical Analysis"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The effects of pressure and co\u2010solvent on the extraction of anti\u2010in\ufb02ammatory faradiol esters in marigold (\n                    <jats:italic>Calendula of\ufb01cinalis<\/jats:italic>\n                    L.) were investigated by supercritical \ufb02uid extraction at laboratory and pilot scales. Pressures higher than 300 bar and modi\ufb01er (ethanol) concentrations ranging from 0 to 20% (v\/v) were used at an extraction temperature of 50 \u00b0C. With an analytical extractor, exhaustive extraction of the drug and highest concentrations in the extracts were achieved with 0.5% ethanol at the maximum pressure of 689 bar. Increased modi\ufb01er concentrations improved the extractability at lower pressure, but the higher amount of total extractables led to a lower concentration of faradiol esters in the extracts. The HPLC \ufb01ngerprints of the extracts, the yields of total extract and the concentration of faradiol esters obtained with analytical and pilot scale extractors under the same conditions were comparable. Copyright \u00a9 2004 John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/pca.772","type":"journal-article","created":{"date-parts":[[2004,6,29]],"date-time":"2004-06-29T11:00:39Z","timestamp":1088506839000},"page":"226-230","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Supercritical carbon dioxide extraction of marigold at high pressures: comparison of analytical and pilot\u2010scale 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