{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:18:37Z","timestamp":1790201917935,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T00:00:00Z","timestamp":1097625600000},"content-version":"vor","delay-in-days":42,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytochemical Analysis"],"published-print":{"date-parts":[[2004,9]]},"abstract":"Abstract<\/jats:title>\n \n The determination of ginkgolic acids in\n Ginkgo<\/jats:italic>\n products is one of the principal components of quality control. However, a number of ginkgolic acids with different side chains may be present and this makes their analysis by conventional chromatographic methods more complex. In this study,\n 1<\/jats:sup>\n H\u2010NMR spectrometry was applied to the analysis of the total content of ginkgolic acids in leaves of\n Ginkgo biloba<\/jats:italic>\n and in six types of commercial\n Ginkgo<\/jats:italic>\n products in the absence of chromatographic puri\ufb01cation. For this analysis, protons H\u20103, H\u20104, and H\u20105, which are well separated in the range\n \u03b4<\/jats:italic>\n (ppm) 6.5\u20137.5 in the\n 1<\/jats:sup>\n H\u2010NMR spectrum, were utilised. For further con\ufb01rmation, the correlations of H\u20103, H\u20104 and H\u20105 were examined by\n 1<\/jats:sup>\n H\u2013\n 1<\/jats:sup>\n H COSY spectra in all extracts. The quantity of the compounds was calculated from the relative ratio of the integral of each peak to the integral of the peaks of a known amount (100 \u00b5g) of anthracene used as an internal standard. The quantitative results obtained by\n 1<\/jats:sup>\n H\u2010NMR analysis were compared with those obtained by GC, which showed that the\n 1<\/jats:sup>\n H\u2010NMR method allows a simple quanti\ufb01cation of total ginkgolic acids in\n Ginkgo<\/jats:italic>\n extracts without any pre\u2010puri\ufb01cation steps. Copyright \u00a9 2004 John Wiley & Sons, Ltd.\n <\/jats:p>","DOI":"10.1002\/pca.786","type":"journal-article","created":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T10:03:05Z","timestamp":1097661785000},"page":"325-330","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Quantitative analysis of ginkgolic acids from\n Ginkgo<\/i>\n leaves and products using\n 1<\/sup>\n H\u2010NMR"],"prefix":"10.1002","volume":"15","author":[{"given":"Young Hae","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung\u2010Kyoon","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. M. G.","family":"Peltenburg\u2010Looman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfons W. M.","family":"Lefeber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Verpoorte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,13]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(02)00172-3"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)01194-3"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pca.2800040604"},{"key":"e_1_2_1_5_1","volume-title":"The Complete German Commission E Monographs\u2014Therapeutic Guide to Herbal Medicines.","author":"Blumenthal M","year":"1998"},{"key":"e_1_2_1_6_1","first-page":"5","volume-title":"Effects of Ginkgo biloba Extract on Organic Cerebral Impairment","author":"Chatterjee SS","year":"1984"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.51.158"},{"key":"e_1_2_1_8_1","first-page":"1529","article-title":"From the body to cell membranes: the different levels of action of Ginkgo biloba","volume":"15","author":"Clostre F","year":"1985","journal-title":"Presse Med"},{"key":"e_1_2_1_9_1","first-page":"331","volume-title":"Ginkgo biloba","author":"Darlington CL","year":"2000"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac60260a042"},{"key":"e_1_2_1_11_1","first-page":"109","volume-title":"Ginkgo biloba","author":"Hasler A","year":"2000"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1046-199X(98)90016-1"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/38.4.169"},{"key":"e_1_2_1_14_1","first-page":"3016","article-title":"Glycerol\u20103\u2010phosphate dehydrogenase inhibitors, anacardic acids, from Ginkgo biloba L","volume":"35","author":"Irie J","year":"1996","journal-title":"Chem Pharm Bull"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00504988"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0192-0561(99)00080-6"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/np50106a021"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0968-0896(95)00081-Q"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00431055"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.16.2282"},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0378-4347(00)00316-9","article-title":"Determination of trace amounts of ginkgolic acids in Ginkgo biloba L. leaf extracts and phytopharmaceuticals by liquid chromatography\u2013electrospray mass spectrometry","volume":"744","author":"Ndjoko K","year":"2000","journal-title":"J. Chromatogr B"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-73739-8"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/pca.2800040408"}],"container-title":["Phytochemical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpca.786","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pca.786","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T11:54:56Z","timestamp":1761047696000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/pca.786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["10.1002\/pca.786"],"URL":"https:\/\/doi.org\/10.1002\/pca.786","archive":["Portico"],"relation":{},"ISSN":["0958-0344","1099-1565"],"issn-type":[{"value":"0958-0344","type":"print"},{"value":"1099-1565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,9]]},"assertion":[{"value":"2003-01-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2003-07-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2004-10-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}