{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:57:13Z","timestamp":1791853033927,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T00:00:00Z","timestamp":1119398400000},"content-version":"vor","delay-in-days":52,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytochemical Analysis"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An HPLC\u2010UV\u2010MS method for the analysis of aristolochic acids A, B, C and D, 7\u2010OH\u2010aristolochic acid A, and aristolic acid in a number of plant materials and their commercial products has been developed. HPLC with photodiode array detection and electrospray ionisation\u2010MS in the selected ion monitoring mode allowed the identification of the target compounds and increased the selectivity of complex analyses such as those associated with multi\u2010botanical preparations. The presented method was used to analyse 10 plant samples and six commercial products that possibly contained aristolochic acids. The resulting chromatographic profiles of the samples were significantly different from each other, and the method was directly transferred to HPLC\u2010MS, which was used to confirm the presence of the six aristolochic acids mentioned above. Copyright \u00a9 2005 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/pca.849","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T13:50:02Z","timestamp":1119448202000},"page":"222-230","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Analysis of aristolochic acids and analogues in medicinal plants and their commercial products by HPLC\u2010PAD\u2010ESI\/MS"],"prefix":"10.1002","volume":"16","author":[{"given":"Feng","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian\u2010Long","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin\u2010Yun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Tao","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian T.","family":"Schaneberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikhlas A.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui\u2010Chao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,22]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/17.4.265"},{"key":"e_1_2_1_3_1","first-page":"323","article-title":"Determination of aristolochic acid I and total alkaloids in Fangji","volume":"19","author":"Chen H","year":"1994","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200326010-00004"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1211\/002235703776944740"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(98)00123-8"},{"key":"e_1_2_1_7_1","first-page":"248","article-title":"Toxicity of Aristolochia plants","volume":"14","author":"Huang ZY","year":"2003","journal-title":"Lishizhen Med Materia Med Res"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(02)00219-3"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(03)00310-8"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1081\/JLC-120025422"},{"key":"e_1_2_1_11_1","first-page":"201","article-title":"Quantitative TLC determination of aristolochic acid in Aristolochia maurorum","volume":"52","author":"Kery A","year":"1981","journal-title":"Fitoterapia"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.611"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(01)00416-9"},{"key":"e_1_2_1_14_1","first-page":"485","article-title":"Quality evaluation of natural compound isolated from crude drugs (Part 2) Aristolochic acid II","volume":"34","author":"Nakamura Y","year":"2003","journal-title":"Iyakuhin Kenkyu"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200006083422301"},{"key":"e_1_2_1_16_1","volume-title":"Pharmacopoeia of the People's Republic of China","year":"2000"},{"key":"e_1_2_1_17_1","first-page":"686","article-title":"Determination of aristolochic acid I and II in north American species of Asarum and Aristolochia","volume":"10","author":"Schaneberg BT","year":"2002","journal-title":"Pharmazie"},{"key":"e_1_2_1_18_1","first-page":"487","article-title":"Quantitation of aristolochic acid using high performance liquid chromatography with photodiode array detection","volume":"78","author":"Singh DV","year":"2001","journal-title":"J Ind Chem Soc"},{"key":"e_1_2_1_19_1","volume-title":"Statutory Instrument no. 1841.","author":"UK Government","year":"2001"},{"key":"e_1_2_1_20_1","unstructured":"US Food and Drug Administration.2000. 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Attachment D\u2014Botanical products determined by FDA to contain aristolochic acids.www.cfsan.fda.gov\/\u223cdms\/ds\u2010bot2.html(accessed 26 August 2002)."},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)92984-2"},{"key":"e_1_2_1_24_1","first-page":"800","article-title":"Preparations of traditional Chinese medicine containing aristolochic acids in Chinese market","volume":"27","author":"Wang ZM","year":"2002","journal-title":"China J Chin Materia Med"},{"key":"e_1_2_1_25_1","first-page":"84","article-title":"The research progress of genus Aristolochia","volume":"12","author":"Wang, Y","year":"2000","journal-title":"Nat Prod Res Dev"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1076\/phbi.34.4.283.13232"}],"container-title":["Phytochemical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpca.849","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pca.849","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T09:33:54Z","timestamp":1761039234000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/pca.849"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["10.1002\/pca.849"],"URL":"https:\/\/doi.org\/10.1002\/pca.849","archive":["Portico"],"relation":{},"ISSN":["0958-0344","1099-1565"],"issn-type":[{"value":"0958-0344","type":"print"},{"value":"1099-1565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,5]]},"assertion":[{"value":"2004-07-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2004-12-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-06-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}