{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:53:10Z","timestamp":1761094390173,"version":"build-2065373602"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,3,31]],"date-time":"2006-03-31T00:00:00Z","timestamp":1143763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytochemical Analysis"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Optimal conditions for the extraction of casearins from <jats:italic>Casearia sylvestris<\/jats:italic> were determined using response surface methodology. The maceration and sonication extraction techniques were performed using a 3 \u00d7 3 \u00d7 3 full factorial design including three acidity conditions, three solvents of different polarities and three extraction times. The yields and selectivities of the extraction of casearins were significantly influenced by acidity conditions. Taking into account all variables tested, the optimal conditions for maceration extraction were estimated to involve treatment with dichloromethane saturated with ammonium hydroxide for 26 h. Similar yields and selectivities for casearins were determined for sonication extraction using the same solvent but for the much shorter time of 1 h. The best results for stabilisation of the fresh plant material were obtained using leaves that had been oven dried at 40\u00b0C for 48 h. Copyright \u00a9 2006 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/pca.902","type":"journal-article","created":{"date-parts":[[2006,3,31]],"date-time":"2006-03-31T08:16:29Z","timestamp":1143792989000},"page":"168-175","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Optimisation of conditions for the extraction of casearins from <i>Casearia sylvestris<\/i> using response surface methodology"],"prefix":"10.1002","volume":"17","author":[{"given":"Karin F.","family":"Bandeira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aristeu G.","family":"Tininis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanderlan da S.","family":"Bolzani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto J.","family":"Cavalheiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,3,31]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_1_2_1","DOI":"10.1590\/S0074-02762000000300012"},{"doi-asserted-by":"publisher","key":"e_1_2_1_3_1","DOI":"10.1016\/0378-8741(90)90007-G"},{"doi-asserted-by":"publisher","key":"e_1_2_1_4_1","DOI":"10.1016\/S0305-0491(00)00237-6"},{"doi-asserted-by":"publisher","key":"e_1_2_1_5_1","DOI":"10.1016\/S0041-0101(01)00169-6"},{"doi-asserted-by":"publisher","key":"e_1_2_1_6_1","DOI":"10.1016\/S0031-9422(98)00249-0"},{"key":"e_1_2_1_7_1","first-page":"220","volume-title":"T\u00f3picos Especiais em Tecnologia de Produtos Naturais","author":"Costa CML","year":"1998"},{"doi-asserted-by":"publisher","key":"e_1_2_1_8_1","DOI":"10.1590\/S0104-66322000000300010"},{"doi-asserted-by":"publisher","key":"e_1_2_1_9_1","DOI":"10.1248\/cpb.38.3384"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/jaoac\/84.2.309","article-title":"Comparison of methods for extraction of tobacco alkaloids","volume":"84","author":"Jones NM","year":"2001","journal-title":"JAOAC Int"},{"doi-asserted-by":"publisher","key":"e_1_2_1_11_1","DOI":"10.1021\/jf991086m"},{"doi-asserted-by":"publisher","key":"e_1_2_1_12_1","DOI":"10.1016\/S0896-8446(00)00047-4"},{"doi-asserted-by":"publisher","key":"e_1_2_1_13_1","DOI":"10.1248\/cpb.39.693"},{"doi-asserted-by":"publisher","key":"e_1_2_1_14_1","DOI":"10.1021\/np010459m"},{"key":"e_1_2_1_15_1","first-page":"73","article-title":"Gua\u00e7atonga (Casearia sylvestris Swartz): aspectos bot\u00e2nicos da planta, ensaios fitoqu\u00edmicos e propriedade cicatrizante da folha","volume":"19","author":"Scavone O","year":"1979","journal-title":"Anais Farm Qu\u00edm S\u00e3o Paulo"},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1076\/1388-0209(200004)3821-1FT112","article-title":"Anti\u2010ulcer activity of the crude extract from the leaves of Casearia sylvestris","volume":"38","author":"Serti\u00e9 JAA","year":"2000","journal-title":"Pharm Biol"},{"key":"e_1_2_1_17_1","first-page":"205","volume-title":"T\u00f3picos Especiais em Tecnologia de Produtos Naturais","author":"Taqueda MES","year":"1998"}],"container-title":["Phytochemical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpca.902","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pca.902","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T16:32:02Z","timestamp":1761064322000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/pca.902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3,31]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["10.1002\/pca.902"],"URL":"https:\/\/doi.org\/10.1002\/pca.902","archive":["Portico"],"relation":{},"ISSN":["0958-0344","1099-1565"],"issn-type":[{"type":"print","value":"0958-0344"},{"type":"electronic","value":"1099-1565"}],"subject":[],"published":{"date-parts":[[2006,3,31]]},"assertion":[{"value":"2005-09-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-12-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-03-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}