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We aimed to elucidate the relationship between the single nucleotide polymorphisms (SNPs) in the COMT gene and the severity of positive and negative symptoms. In order to investigate the relationship, the PubMed, PubMed Central, Scopus, and Cochrane CENTRAL databases were screened for eligible articles. Thirty\u2010eight studies, including 4443 adult patients with schizophrenia, were included in the quantitative analyses, and four studies were qualitatively assessed. Quantitative analyses were performed for acutely ill and clinically stable patient subgroups regarding the different genotypes of rs4680 SNP. Our results showed that the severity of negative symptoms was higher in patients who were rs4680 Met homozygous compared to Val\/Met heterozygotes only in acutely ill samples. There was no other significant difference between genotypes. Meta\u2010regression did not reveal any significant moderator effect on the difference in negative symptoms. General psychopathology, positive, negative, and total psychotic symptom levels also were similar between Val homozygotes and Met carriers. Nonetheless, there are some limitations in the study. First, SNPs except for rs4680 were under\u2010researched because of the limited number of studies. Second, high heterogeneity across studies was the main concern. Our results suggested that the COMT rs4680 Met allele was associated with higher levels of negative symptoms within acutely ill patients. Future studies should focus on specific patient subgroups to reveal the moderating effects of SNPs.<\/jats:p>","DOI":"10.1002\/pchj.562","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T05:55:05Z","timestamp":1654062905000},"page":"779-791","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The effects of <scp>catechol\u2010O\u2010methyltransferase<\/scp> single nucleotide polymorphisms on positive and negative symptoms of schizophrenia: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8953-1171","authenticated-orcid":false,"given":"Emre","family":"Misir","sequence":"first","affiliation":[{"name":"Department of Psychiatry Baskent University Faculty of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mutlu Muhammed","family":"Ozbek","sequence":"additional","affiliation":[{"name":"Child and Adolescent Psychiatry Clinic Kars State Hospital  Kars Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eren","family":"Halac","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry Dokuz Eylul University Faculty of Medicine  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serkan","family":"Turan","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry Uluda\u011f University Faculty of Medicine  Bursa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gokce Elif","family":"Alkas","sequence":"additional","affiliation":[{"name":"Child and Adolescent Psychiatry Bak\u0131rk\u00f6y Mazhar Osman Mental Health and Neurological Diseases Education and Research Hospital  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remzi Ogulcan","family":"Ciray","sequence":"additional","affiliation":[{"name":"Child and Adolescent Psychiatry Clinic Mardin State Hospital  Mardin Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cagatay","family":"Ermis","sequence":"additional","affiliation":[{"name":"Child and Adolescent Psychiatry Clinic Diyarbak\u0131r Children Hospital  Diyarbak\u0131r Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,31]]},"reference":[{"issue":"10","key":"e_1_2_8_2_1","first-page":"1301","article-title":"Diagnostic and statistical manual of mental disorders (3rd ed., revised)","volume":"145","author":"American Psychiatric Association","year":"1980","journal-title":"American Journal of Psychiatry"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890423349"},{"key":"e_1_2_8_4_1","first-page":"1228\u20131228","volume-title":"Diagnostic and statistical manual of mental disorders (4th ed., text rev. ed.)","author":"American Psychiatric Association","year":"2000"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1192\/S0007125000291496"},{"key":"e_1_2_8_7_1","volume-title":"Scale for the assessment of positive symptoms (SAPS)","author":"Andreasen N. 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