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This study examined how BMI and gender are associated with depression\u2010anxiety symptom networks in 9091 Chinese adults aged 19\u201365\u2009years using the Patient Health Questionnaire\u20109 (PHQ\u20109) and the Generalized Anxiety Disorder\u20107 (GAD\u20107) scales. Participants were categorized into four BMI subgroups: underweight, normal weight, overweight, and obesity groups. Network analysis identified core symptoms, including \u201cmotor problems\u201d (PHQ8), \u201cuncontrollable worry\u201d (GAD2), and \u201ctrouble relaxing\u201d (GAD4). Differences in network structure were observed across BMI groups, with males showing variations between the underweight, normal weight, and obesity groups, and females demonstrating significant differences in both network structure and global strength between the underweight and overweight groups. Gender differences were also found in the global strength of the overall network and in the network structure of the normal weight group. Limitations include potential residual confounders, the cross\u2010sectional design, reliance on self\u2010reported data, and unbalanced sample sizes. These findings suggest that BMI may be associated with the depression\u2010anxiety symptom network in Chinese adults, with distinct gender\u2010specific patterns, highlighting the importance of considering both BMI and gender in developing targeted mental health interventions.<\/jats:p>","DOI":"10.1002\/pchj.70104","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T07:56:37Z","timestamp":1780041397000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Gender\u2010Specific Depression\u2010Anxiety Symptom Networks and the Impact of Weight Status: Insights From a Large\u2010Scale Study"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0656-9861","authenticated-orcid":false,"given":"Meng\u2010Bi","family":"Yang","sequence":"first","affiliation":[{"name":"School of Mechanical Engineering, Northwestern Polytechnical University  Xi'an 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