{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:04:50Z","timestamp":1753869890770,"version":"3.41.2"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:00:00Z","timestamp":1687910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PCN Reports"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Clinicians face difficulties in making treatment decisions for unspecified anxiety disorder due to the absence of any treatment guidelines. The objective of this study was to investigate how familiar and how often primary care physicians use pharmacological and nonpharmacological approaches to manage the disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A survey was conducted among 117 primary care physicians in Japan who were asked to assess the familiarity of using each treatment option for unspecified anxiety disorder on a binary response scale (0\u2009=\u2009\u201cunfamiliar,\u201d 1\u2009=\u2009\u201cfamiliar\u201d) and the frequency on a nine\u2010point Likert scale (1\u2009=\u2009\u201cnever used,\u201d 9\u2009=\u2009\u201cfrequently used\u201d).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>While several benzodiazepine anxiolytics were familiar to primary care physicians, the frequencies of prescribing them, including alprazolam (4.6\u2009\u00b1\u20092.6), ethyl loflazepate (3.6\u2009\u00b1\u20092.4), and clotiazepam (3.5\u2009\u00b1\u20092.3), were low. In contrast, certain nonpharmacological options, including lifestyle changes (5.4\u2009\u00b1\u20092.3), coping strategies (5.1\u2009\u00b1\u20092.7), and psychoeducation for anxiety (5.1\u2009\u00b1\u20092.7), were more commonly utilized, but to a modest extent. When a benzodiazepine anxiolytic drug failed to be effective, primary care physicians selected the following management strategies to a relatively high degree: differential diagnosis (6.4\u2009\u00b1\u20092.4), referral to a specialist hospital (5.9\u2009\u00b1\u20092.5), lifestyle changes (5.2\u2009\u00b1\u20092.5), and switching to selective serotonin reuptake inhibitor (5.1\u2009\u00b1\u20092.4).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Primary care physicians exercise caution when prescribing benzodiazepine anxiolytics for unspecified anxiety disorder. Nonpharmacological interventions and switching to SSRI are modestly employed as primary treatment options and alternatives to benzodiazepine anxiolytics. To ensure the safe and effective treatment of unspecified anxiety disorder in primary care, more information should be provided from field experts.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pcn5.118","type":"journal-article","created":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T04:01:29Z","timestamp":1688011289000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical practice for unspecified anxiety disorder in primary care"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5399-7946","authenticated-orcid":false,"given":"Hitoshi","family":"Sakurai","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry Kyorin University Faculty of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Takeshima","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Akita University Graduate School 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