{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T17:53:04Z","timestamp":1779904384687,"version":"3.53.1"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T00:00:00Z","timestamp":1694390400000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PCN Reports"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Delayed neuropsychiatric sequelae (DNS) occurs in 10%\u201330% of acute carbon monoxide poisoning cases. Patients with this condition present higher brain dysfunction. Hyperbaric oxygen (HBO) therapy was reportedly an effective treatment for DNS in the acute phase. Favorable predictive factors affecting the prognosis of patients with DNS after HBO therapy include younger age and longer interictal periods. However, the relationship between these factors and neuroimaging findings remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>The patient was a 59\u2010year\u2010old man with DNS, who developed major depressive disorder and attempted suicide with charcoal briquettes. He was diagnosed with carbon monoxide poisoning and underwent acute HBO therapy. After a 1\u2010month lucid period, the patient developed intermittent carbon monoxide poisoning with cognitive dysfunction, following which HBO therapy was re\u2010initiated. Following treatment, the patient returned to work for 10 years. Frontal lobe hypoperfusion, measured by single\u2010photon emission computed tomography and cognitive impairment, improved with HBO therapy. However, magnetic resonance imaging revealed brain volume atrophy over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study reported a case of DNS that completely resolved within a 10\u2010year follow\u2010up period. Cerebral blood flow reduction, mainly in the frontal lobe, improved along with cognitive recovery during HBO therapy. Despite gradually progressive brain atrophy over the past decade, no noted deficits in cerebral blood flow were observed in the frontal lobes. These findings suggest that improvement in cerebral blood flow during HBO therapy and its retention may be factors associated with a favorable prognosis in patients with DNS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pcn5.139","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T04:44:20Z","timestamp":1694493860000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Delayed neuropsychiatric sequelae with improvement of decreased cerebral bold flow by single\u2010photon emission computed tomography during hyperbaric oxygen therapy: A case report with a 10\u2010year follow\u2010up"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7534-4308","authenticated-orcid":false,"given":"Kosuke","family":"Hagiwara","sequence":"first","affiliation":[{"name":"Division of Neuropsychiatry, Department of Neuroscience Yamaguchi University Graduate School of Medicine  Ube Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5495-0859","authenticated-orcid":false,"given":"Toshio","family":"Matsubara","sequence":"additional","affiliation":[{"name":"Division of Neuropsychiatry, Department of Neuroscience Yamaguchi University Graduate School of Medicine  Ube Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7502-5734","authenticated-orcid":false,"given":"Shin","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Division of Neuropsychiatry, Department of Neuroscience Yamaguchi University Graduate School of Medicine  Ube Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,11]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"World Health Organization. Suicide worldwide in 2019;2019. Available from:https:\/\/www.who.int\/publications\/i\/item\/9789240026643"},{"key":"e_1_2_12_3_1","unstructured":"The Ministry of Health LaW. Dynamic of population statistics in 2019;2019."},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/00048674221114605"},{"key":"e_1_2_12_5_1","unstructured":"The Ministry of Health Labour and Welfare of Japan.Situation of suicide in 2019;2019.\u00a0Available fromhttps:\/\/www.mhlw.go.jp\/content\/r2h-1-6.pdf"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/00048674221114605"},{"key":"e_1_2_12_7_1","first-page":"23","article-title":"Hyperbaric oxygen ameliorates delayed neuropsychiatric syndrome of carbon monoxide poisoning","volume":"37","author":"Chang DC","year":"2010","journal-title":"Undersea Hyperb Med"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-98539-y"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0253602"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2009.09.030"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2011.07.002"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2011.07.002"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5979"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2014.01.005"},{"key":"e_1_2_12_15_1","first-page":"57","article-title":"Utilizing cerebral perfusion scan and diffusion\u2010tensor MR imaging to evaluate the effect of hyperbaric oxygen therapy in carbon monoxide\u2010induced delayed neuropsychiatric seqeulae\u2014a case report and literature review","volume":"24","author":"Lin YT","year":"2015","journal-title":"Acta Neurol Taiwan"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2013.03.004"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2017.00508"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2020.10.062"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6663824"}],"container-title":["Psychiatry and Clinical Neurosciences Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pcn5.139","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T08:32:51Z","timestamp":1695717171000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pcn5.139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1002\/pcn5.139"],"URL":"https:\/\/doi.org\/10.1002\/pcn5.139","archive":["Portico"],"relation":{},"ISSN":["2769-2558","2769-2558"],"issn-type":[{"value":"2769-2558","type":"print"},{"value":"2769-2558","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"2023-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e139"}}