{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:51:10Z","timestamp":1777495870130,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K16643"],"award-info":[{"award-number":["20K16643"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PCN Reports"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We present a case report on the efficacy of the short\u2010term application of vortioxetine in managing winter depression in patients with seasonal bipolar disorder (BP). Standard treatment strategies for BP may not adequately address seasonal depressive symptoms during winter in patients with seasonal BP patterns. Depressive symptoms during winter may be linked to seasonal changes in serotonin transporter binding, such as a decrease in synaptic serotonin levels, necessitating alternative approaches. Although antidepressants, including vortioxetine, are effective in treating seasonal monopolar depression, their efficacy and safety in treating depression in patients with seasonal BP patterns remain unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>This case report focuses on a 44\u2010year\u2010old male patient diagnosed with seasonal BP who had recurrent depressive episodes, specifically during winter. Notably, the patient had a significant decrease in recurrent episodes after short\u2010term seasonal vortioxetine use without inducing mania or rapid cycling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study highlights the potential effectiveness of a seasonal, short\u2010term treatment strategy with antidepressants, including vortioxetine, for winter depression in individuals with BP.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pcn5.163","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T06:43:30Z","timestamp":1704955410000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effectiveness of vortioxetine for winter depression in bipolar disorder: A case report"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9296-7398","authenticated-orcid":false,"given":"Yusei","family":"Yamaguchi","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Tokyo Medical and Dental University Graduate School  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7289-6553","authenticated-orcid":false,"given":"Shunsuke","family":"Takagi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Tokyo Medical and Dental University Graduate School  Tokyo Japan"},{"name":"Sleep Research Institute Waseda University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidehiko","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Tokyo Medical and Dental University Graduate School  Tokyo Japan"},{"name":"Center for Brain Integration Research Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genichi","family":"Sugihara","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Tokyo Medical and Dental University Graduate School  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.07.002"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/07420528.2013.800091"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.65.9.1072"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-004-0014-z"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2012.04.006"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.152.12.1765"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1399-5618.2003.00083.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12609"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.03.007"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2016.54"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/07420528.2012.741172"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2006.06.026"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/07420529409057240"}],"container-title":["Psychiatry and Clinical Neurosciences Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pcn5.163","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T08:00:06Z","timestamp":1711440006000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pcn5.163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,10]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/pcn5.163"],"URL":"https:\/\/doi.org\/10.1002\/pcn5.163","archive":["Portico"],"relation":{},"ISSN":["2769-2558","2769-2558"],"issn-type":[{"value":"2769-2558","type":"print"},{"value":"2769-2558","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,10]]},"assertion":[{"value":"2023-09-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e163"}}