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Symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS), Young Mania Rating Scale, 21\u2010item Hamilton Depression Rating Scale (HAMD\u201021), and Pittsburgh Sleep Quality Index (PSQI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The IPSM interpersonal awareness, separation anxiety, timidity, fragile inner self, and total scores were significantly higher in all the patient groups compared with healthy individuals (corrected <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The IPSM need for approval score was significantly higher in patients with BD \u2160 and those with BD \u2161 than in those with schizophrenia or MDD (corrected <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The PSQI total score and PANSS general psychopathology score, HAMD\u201021 delusion subscale score, HAMD\u201021 total score, and HAMD\u201021 core subscale score and PSQI sleep disturbance subscale score were significantly and positively correlated with the IPSM total score in patients with schizophrenia, those with BD \u2160, those with BD \u2161, and those with MDD, respectively, while the PSQI total score and daytime dysfunction subscale score were significantly and positively correlated with the IPSM total score in healthy individuals (corrected <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data suggest that higher interpersonal sensitivity may play a role in the development of major psychiatric disorders and may be involved in some clinical symptom 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