{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:04:56Z","timestamp":1753869896810,"version":"3.41.2"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T00:00:00Z","timestamp":1709683200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PCN Reports"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To date, only a few reports of anti\u2010LGI1 encephalitis with isolated psychiatric symptoms in the initial phase have been reported. We present a relatively rare case of antileucine\u2010rich glioma\u2010inactivated 1 (LGI1) encephalitis that developed only psychiatric symptoms at the onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>The patient was a male in his 40s who developed anxiety and panic symptoms and was started on antidepressants after being diagnosed with panic disorder by a psychiatrist. He visited our hospital 2 months later presenting with hallucinations, delusions, mild cognitive decline, and faciobrachial dystonic seizures in the left upper extremity and face. Fluid\u2010attenuated inversion recovery magnetic resonance imaging revealed swelling and hyperintensities in the right caudate nucleus and putamen. Cerebrospinal fluid analysis did not show increased protein levels or cell counts and revealed positive oligoclonal bands. Subsequently, positive results for anti\u2010LGI1 antibodies were observed in the cerebrospinal fluid. Therefore, the patient was diagnosed with anti\u2010LGI1 encephalitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This case highlights the need to consider anti\u2010LGI1 encephalitis therapy in patients with acute\u2010onset psychiatric symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pcn5.181","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T08:23:56Z","timestamp":1709713436000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anti\u2010LGI1 encephalitis preceded by psychiatric symptoms: A case report"],"prefix":"10.1002","volume":"3","author":[{"given":"Takuma","family":"Numazawa","sequence":"first","affiliation":[{"name":"Department of Psychiatry Yamagata University School of Medicine Yamagata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4213-618X","authenticated-orcid":false,"given":"Ryota","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yamagata University School of Medicine Yamagata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9118-0363","authenticated-orcid":false,"given":"Toshinori","family":"Shirata","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yamagata University School of Medicine Yamagata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Neurology and Clinical Neuroscience, Department of Internal Medicine III Yamagata University School of Medicine Yamagata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyasu","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Neurology and Clinical Neuroscience, Department of Internal Medicine III Yamagata University School of Medicine Yamagata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Animal Model Development, Brain Research Institute Niigata University Niigata Japan"},{"name":"Department of Multiple Sclerosis Therapeutics, School of Medicine Fukushima Medical University Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihito","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yamagata University School of Medicine Yamagata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13324"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.606350"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.674368"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00401-9"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.3216"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2023.1168302"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-021-05134-0"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.47936\/encephalitis.2022.00080"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1708712"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22307"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000161"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2007.9.2\/rbonelli"}],"container-title":["Psychiatry and Clinical Neurosciences Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pcn5.181","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T08:02:29Z","timestamp":1711440149000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pcn5.181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/pcn5.181"],"URL":"https:\/\/doi.org\/10.1002\/pcn5.181","archive":["Portico"],"relation":{},"ISSN":["2769-2558","2769-2558"],"issn-type":[{"type":"print","value":"2769-2558"},{"type":"electronic","value":"2769-2558"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"2023-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e181"}}