{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T21:06:42Z","timestamp":1773176802008,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PCN Reports"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Delusional disorder, somatic type (DDST) is characterized by the presence of persistent delusions related to having a physical illness or bodily dysfunction, despite contradictory medical evidence. Antipsychotics like pimozide have shown efficacy in the treatment of DDST, and several case reports suggest that antidepressants may also be effective for this disorder. We are the first to report the effectiveness of escitalopram, which is a most selective and potent serotonin reuptake inhibitor, in a patient with DDST.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>The case was a 62\u2010year\u2010old woman with DDST, presenting with oral somatic delusions. Escitalopram treatment (10\u2009mg\/day, increased to 20\u2009mg\/day) led to significant symptom improvement, and the symptoms of DDST had nearly resolved \u223c5 weeks after the initiation of escitalopram. Single\u2010photon emission computed tomography imaging during DDST symptoms showed reduced regional cerebral blood flow (rCBF) in the cerebral cortex, particularly in the temporal and parietal lobes, with follow\u2010up imaging after 9 weeks of escitalopram treatment demonstrating rCBF improvement correlating with clinical recovery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This case suggests that escitalopram was effective in treating DDST, providing further support for the involvement of serotonergic dysfunction in the pathophysiology of DDST. The improvement in rCBF following treatment suggests that DDST may be associated with reduced rCBF in the temporal and parietal lobes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pcn5.70067","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T09:52:36Z","timestamp":1741773156000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Successful treatment of delusional disorder, somatic type by escitalopram: A case report and literature review"],"prefix":"10.1002","volume":"4","author":[{"given":"Yunosuke","family":"Mizuno","sequence":"first","affiliation":[{"name":"Department of Psychiatry Yamagata University Faculty of Medicine Yamagata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Sugai","sequence":"additional","affiliation":[{"name":"Department of Radiology, Division of Diagnostic Radiology, Faculty of Medicine Yamagata University Yamagata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9118-0363","authenticated-orcid":false,"given":"Toshinori","family":"Shirata","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yamagata University Faculty of Medicine Yamagata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4213-618X","authenticated-orcid":false,"given":"Ryota","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yamagata University Faculty of Medicine Yamagata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Noto","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yamagata University Faculty of Medicine Yamagata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yamagata University Faculty of Medicine Yamagata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Kanoto","sequence":"additional","affiliation":[{"name":"Department of Radiology, Division of Diagnostic Radiology, Faculty of Medicine Yamagata University Yamagata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihito","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yamagata University Faculty of Medicine Yamagata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1192\/S0007125000298978"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNF.0b013e3181c1cfe4"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.590"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-5846(98)00098-0"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10123281"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/npr2.12384"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-8301.2012.00430.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNF.0b013e3181dca95e"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-199905030-00006"},{"key":"e_1_2_11_12_1","first-page":"1477","article-title":"A case with fear of emitting body odour resulted in successful treatment with clomipramine","volume":"69","author":"Kizu A","year":"1994","journal-title":"[Hokkaido igaku zasshi] Hokkaido J Medl Sci"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.152.6.851"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-198803000-00010"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.141.12.1608"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/070674378302800131"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.142.10.1223b"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.142.12.1518b"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200317050-00004"},{"key":"e_1_2_11_20_1","unstructured":"DrugBank database. 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