{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T07:49:04Z","timestamp":1785656944671,"version":"3.56.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23WM0425019"],"award-info":[{"award-number":["JP23WM0425019"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PCN Reports"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pick's disease (PiD) is a subtype of frontotemporal lobar degeneration. However, the pathogenesis and symptomatic lesions remain unclear. We report a case of PiD with a short disease duration and compare it to a case series to reveal the association between degenerative patterns and clinical manifestations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>The patient showed a marked decline in motivation at the age of 54 years. He was admitted with a clinical diagnosis of depressive disorder at the age of 56 years. He exhibited only apathy and lacked typical behavioral symptoms. Specialist observation revealed behavioral symptoms such as\u00a0disinhibition, a lack of empathy, and hyperorality that had previously unnoticed by the patient's family members. The patient died of acute heart failure 4 days after hospitalization. Postmortem examination revealed a brain weight of 1090\u2009g, with focal atrophy of the bilateral frontal and temporal lobes. Neuropathological findings mainly presented as numerous Pick bodies (PBs), mainly in the frontal lobe and hippocampus. PBs were immunopositive for phosphorylated tau and 3\u2010repeat tau but negative for 4\u2010repeat tau. The pathological findings in this case corresponded to phase II of PiD staging as defined in a previous study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The clinical symptoms in this case, primarily characterized by apathy with minimal behavioral symptoms, were consistent with the predominant pathological involvement of the dorsolateral frontal lobe. The present case was interpreted as early\u2010phase PiD. A comparison of the case series suggested that early\u2010phase PiD cases may help clarify the association between early clinical manifestations and focal degenerative lesions in the frontal lobe.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pcn5.70116","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T07:05:32Z","timestamp":1746687932000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical neuropathology of early\u2010stage Pick's disease initially diagnosed as depressive disorder: A case report and case series comparison"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7710-9364","authenticated-orcid":false,"given":"Araki","family":"Kimura","sequence":"first","affiliation":[{"name":"Dementia Research Project Tokyo Metropolitan Institute of Medical Science Setagaya Tokyo Japan"},{"name":"Department of Psychiatry and Behavioral science Juntendo 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