{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T15:18:47Z","timestamp":1783091927574,"version":"3.54.6"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T00:00:00Z","timestamp":1751760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PCN Reports"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Postoperative delirium (POD) is a severe neuropsychiatric state characterized by acute fluctuating various mental symptoms. Despite its prevalence, the underlying mechanisms of POD remain largely unknown, and effective biomarkers for its detection are lacking. We have successfully developed a novel delirium detection method, the bispectral electroencephalography (BSEEG) method, which has shown excellent performance in delirium detection and outcome prediction. From there, like the clinical situation, we hypothesize that BSEEG scores can serve as indicators of POD\u2010like states in mice. This study investigated the correlation between POD\u2010like behavior and BSEEG score in a mouse model following EEG head\u2010mount implantation surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>First, 2\u20133\u2010 and 22\u201323\u2010month\u2010old male C57BL\/6J mice underwent EEG head\u2010mount implantation surgery, followed by EEG monitoring and a battery of behavioral tests, including the buried food test, the open field test, and the Y\u2010maze, to assess POD\u2010like behavior. We measured BSEEG scores and analyzed the correlation between these scores and the behavior measurements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The results showed BSEEG scores correlated with attention deficit and decreases in locomotor activity in young mice, whilst BSEEG scores only correlated with a decrease in locomotor activity in aged mice. Notably, composite\n                      <jats:italic>Z<\/jats:italic>\n                      scores representing delirium severity also showed a correlation with BSEEG scores in young mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings indicate that the BSEEG method can be an indicator of POD\u2010like states consistent with those measured by behavior tests. This study provides a novel preclinical framework for understanding the pathophysiology of POD and underscores the potential of BSEEG as a valuable tool for delirium detection and severity assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pcn5.70142","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:57:14Z","timestamp":1751849834000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The age\u2010related susceptibility to postoperative delirium quantified by bispectral electroencephalography correlates with postoperative delirium\u2010like behavior in mice"],"prefix":"10.1002","volume":"4","author":[{"given":"Tsuyoshi","family":"Nishiguchi","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Stanford University School of Medicine Palo Alto California USA"},{"name":"Department of Neuropsychiatry, Faculty of Medicine Tottori University Yonago Tottori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyosuke","family":"Yamanishi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Stanford University School of Medicine Palo Alto California USA"},{"name":"Department of Neuropsychiatry, School of Medicine Hyogo Medical University Nishinomiya Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiyoshi","family":"Shimura","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Stanford University School of Medicine Palo Alto California USA"},{"name":"Department of Psychiatry Tokyo Medical University Shinjuku\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2593-7118","authenticated-orcid":false,"given":"Tomoteru","family":"Seki","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Stanford University School of Medicine Palo Alto California USA"},{"name":"Department of Psychiatry Tokyo Medical University Shinjuku\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaya","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Stanford University School of Medicine Palo Alto California USA"},{"name":"iPS Cell\u2010Based Drug Discovery Group, Regenerative &amp; Cellular Medicine Kobe Center, Sumitomo Pharma Co. 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