{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:42:43Z","timestamp":1787244163500,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PCN Reports"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The coronavirus disease 2019 (SARS\u2010COV\u20102) pandemic has been associated with an increased risk of developing or exacerbating obsessive\u2010compulsive disorder (OCD). This report presents a case of OCD onset in a 50\u2010year\u2010old male following recovery from acute SARS\u2010COV\u20102 infection, highlighting the potential neuroinflammatory and neuroimmune mechanisms involved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>Mr. A, a 50\u2010year\u2010old cook with no prior psychiatric history, developed a loss of smell and taste by SARS\u2010COV\u20102. This sensory impairment triggered severe anxiety, leading to compulsive checking behaviors and reassurance\u2010seeking after recovering from SARS\u2010COV\u20102. Initial treatment with fluvoxamine at 50\u2009mg\/day was insufficient, and his symptoms necessitated inpatient care. His compulsive behaviors continued during hospitalization, and escalation of fluvoxamine to 150\u2009mg\/day, alongside adjunctive risperidone at 3\u2009mg\/day was needed. Along with cognitive\u2010behavioral therapy (CBT) advises, this resulted in symptom stabilization and eventual discharge. Postdischarge, Mr. A's OCD symptoms remained stable with ongoing medication, despite continued sensory disturbances.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case illustrates the atypical onset of OCD in an older adult following SARS\u2010COV\u20102 infection, potentially driven by neuroinflammation and altered neural pathways. The partial response to fluvoxamine and the need for risperidone suggest that SARS\u2010COV\u20102\u2010related OCD may involve complex neuroimmune changes beyond serotonin dysregulation. This case emphasizes the importance of recognizing neuropsychiatric complications in SARS\u2010COV\u20102 survivors and underscores the need for further research into the mechanisms and management of SARS\u2010COV\u20102\u2010related neuropsychiatric symptoms, including OCD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pcn5.70148","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T08:43:18Z","timestamp":1752223398000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Atypical onset of obsessive\u2010compulsive disorder at age 50 following post\u2010SARS\u2010COV\u20102 syndrome: A case report"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8105-9466","authenticated-orcid":false,"given":"Tomoko","family":"Sugawara","sequence":"first","affiliation":[{"name":"Department of Psychiatry Komagino Hospital Hachioji Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rie","family":"Ichiki","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Komagino Hospital Hachioji Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.806872"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2024.02.031"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocrd.2021.100626"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.5708\/EJMH.17.2022.2.13"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(23)00239-4"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1463423622000585"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202009-1175OC"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2023-082439"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/npr2.12495"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.2200"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.592214"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03710-0"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-022-03709-7"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000001046"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/10600280231162243"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyv047"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/npr2.12222"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-024-05899-6"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadr.2021.100156"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/19390211.2021.1922567"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2021.11.025"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1037\/\/0735-7044.112.6.1475"}],"container-title":["Psychiatry and Clinical Neurosciences Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pcn5.70148","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T10:41:00Z","timestamp":1758796860000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pcn5.70148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,11]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/pcn5.70148"],"URL":"https:\/\/doi.org\/10.1002\/pcn5.70148","archive":["Portico"],"relation":{},"ISSN":["2769-2558","2769-2558"],"issn-type":[{"value":"2769-2558","type":"print"},{"value":"2769-2558","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,11]]},"assertion":[{"value":"2025-02-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70148"}}