{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T19:25:19Z","timestamp":1780514719119,"version":"3.54.1"},"reference-count":9,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PCN Reports"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In rare instances, Parkinson's disease may develop in patients with schizophrenia receiving antipsychotic treatment, highlighting the need for comprehensive clinical evaluation and imaging investigations. We present a case of schizophrenia coexisting with suspected familial Parkinson's disease, characterized by a discrepancy between dopamine transportor single photon emission computed tomography (DAT SPECT) and <jats:sup>123<\/jats:sup>I meta\u2010iodo benzylguanidine (MIBG) myocardial scintigraphy results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>The patient was a woman in her 50s who first exhibited paranoid delusions and auditory hallucinations in her 20s and was continuously treated on an outpatient basis for schizophrenia. Three years ago, she sought consultation at a neurology clinic due to resting tremor in the right upper limb and difficulty walking. Given the asymmetry of her symptoms and the notable decrease in left\u2010sided uptake observed on the DAT SPECT, she was diagnosed with Parkinson's disease, and her symptoms improved with levodopa therapy. One year later, she developed lower limb rigidity and weakness, and was seen at another hospital's neurology department. Despite these findings, MIBG myocardial scintigraphy revealed no significant uptake reduction, leading to a diagnosis of drug\u2010induced parkinsonism. After reducing both anti\u2010Parkinson's and antipsychotic medications, her auditory hallucinations and motor difficulties worsened, prompting her referral to our department for inpatient care. On reassessment, Parkinson's disease was confirmed and anti\u2010Parkinson's medication was reintroduced, leading to improvement in her motor symptoms without exacerbation of psychiatric symptoms, and she was discharged home.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prompt and accurate diagnosis through detailed clinical evaluation and appropriate imaging studies is crucial for the effective management of both schizophrenia and parkinsonism, ensuring optimal control of both conditions.<\/jats:p><jats:p><jats:bold>Clinical trial registration<\/jats:bold>. This report is not a clinical trial<\/jats:p><\/jats:sec>","DOI":"10.1002\/pcn5.70149","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T05:29:08Z","timestamp":1753162148000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A case of schizophrenia with Parkinson's disease: Reduced dopamine transporter binding in unilateral striatum and normal uptake pattern of 123I\u2010MIBG myocardial scintigraphy"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7095-8404","authenticated-orcid":false,"given":"Ken","family":"Wada","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Hiroshima Citizens Hospital Hiroshima City Hospital Organization Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Oga","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Hiroshima Citizens Hospital Hiroshima City Hospital Organization Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nozomu","family":"Minao","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Hiroshima Citizens Hospital Hiroshima City Hospital Organization Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Sugita","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Cocoro Hospital Kusatsu Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,21]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-010-0068-4"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-008-0428-5"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20594"},{"key":"e_1_2_12_5_1","volume-title":"Clinical Assessment of Autonomic Nervous System","author":"Orimo S","year":"2016"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/IJPSYM.IJPSYM_68_17"},{"issue":"2","key":"e_1_2_12_7_1","first-page":"179","article-title":"Idiopathic Parkinson's disease and schizophrenia: dilemma in diagnosis and treatment of a case","volume":"14","author":"Sharma S","year":"2019","journal-title":"Iran J Psychiatry"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2021-244028"},{"issue":"1","key":"e_1_2_12_9_1","first-page":"85","article-title":"A patient of schizophrenia with juvenile Parkinson's disease: the evaluation of 123I\u2010MIBG myocardial scintigrapy and 123I\u2010Ioflupane SPECT (DaTSCAN) image","volume":"60","author":"Hayashi M","year":"2018","journal-title":"Seishinigaku"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28484"}],"container-title":["Psychiatry and Clinical Neurosciences Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pcn5.70149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T10:41:08Z","timestamp":1758796868000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pcn5.70149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,21]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/pcn5.70149"],"URL":"https:\/\/doi.org\/10.1002\/pcn5.70149","archive":["Portico"],"relation":{},"ISSN":["2769-2558","2769-2558"],"issn-type":[{"value":"2769-2558","type":"print"},{"value":"2769-2558","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,21]]},"assertion":[{"value":"2025-03-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70149"}}