{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:44:27Z","timestamp":1790300667107,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K14791"],"award-info":[{"award-number":["23K14791"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PCN Reports"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the relationship between the prescription of novel hypnotics (melatonin receptor agonists [MRAs] and orexin receptor antagonists [ORAs]) and the risk of hip fractures in a large cohort of Japanese patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective study, we analyzed data from a large health insurance claims database. Among subscribers aged \u226550 years between April 2014 and September 2021, those assigned the disease code of hip fracture were included. Each patient's prescription history for hypnotics was examined to identify the exposure and non\u2010exposure periods. The relationship between exposure to hypnotics and the development of hip fractures was analyzed using the Mayo\u2010updated Cox proportional hazards regression model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 269,097 patients developed hip fractures. The prescription of any hypnotic was significantly associated with hip fracture incidence (adjusted hazard ratio [aHR], 2.30; 95% confidence interval [CI], 2.27\u20132.32). In the analysis by class of hypnotics, the hazard ratio was highest for ORAs (aHR, 3.09; 95% CI, 3.03\u20133.16), followed by that for MRAs (aHR, 2.45; 95% CI, 2.38\u20132.52).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Novel hypnotics use was significantly associated with the development of hip fractures, and patients prescribed ORAs and MRAs should be cautioned about the risk of hip fractures.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pcn5.70193","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T18:23:52Z","timestamp":1755541432000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Novel hypnotics use and hip fracture risk in middle\u2010aged and older adults: A large, population\u2010based cohort study in Japan"],"prefix":"10.1002","volume":"4","author":[{"given":"Nana","family":"Shibata","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry Akita University Graduate School of Medicine Akita City Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0600-4515","authenticated-orcid":false,"given":"Kazuhisa","family":"Yoshizawa","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Akita University Graduate School of Medicine Akita City Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Takeshima","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Akita University Graduate School of Medicine Akita City Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Department of Sleep\u2010Wake Disorders, National Center of Neurology and Psychiatry National Institute of Mental Health Kodaira Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Ogasawara","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Akita University Graduate School of Medicine Akita City Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizuki","family":"Kudo","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Akita University Graduate School of Medicine Akita City Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Itoh","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Akita University Graduate School of Medicine Akita City Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eru","family":"Miyakoshi","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Akita University Graduate School of Medicine Akita City Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Ayabe","sequence":"additional","affiliation":[{"name":"Department of Regional Studies and Humanities, Faculty of Education and Human Studies Akita University Akita City Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Mishima","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Akita University Graduate School of Medicine Akita City Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,18]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2000.tb00833.x"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2702.2005.01130.x"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2018.04.015"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-015-3464-8"},{"key":"e_1_2_13_6_1","unstructured":"World population prospects: 2024 revision[cited 2025 Mar 8]. 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