{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T15:11:42Z","timestamp":1771168302380,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PCN Reports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To identify the factors associated with the severity and prognosis of coronavirus disease 2019 (COVID\u201019) in patients with psychiatric or neurological disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed the clinical characteristics and treatment outcomes of 349 patients with those disorders who were admitted for COVID\u201019 at the National Center of Neurology and Psychiatry between June 2020 and March 2023. The study period was divided into three phases: June\u2013December 2020, January\u2013December 2021, and January 2022 to March 2023 according to the differences in types of COVID\u201019 variants and our clinical care systems. Differences across phases were analyzed using the Kruskal\u2013Wallis test. Logistic regression was performed to identify factors associated with moderate II or higher COVID\u201019 and all\u2010cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 36 (10.3%), 107 (30.7%), and 206 (59.0%) patients were admitted in the first, second, and third phases, respectively. The average age of the patients was 66.4\u2009\u00b1\u200917.9 years, and 47% of them were female. Aspiration pneumonia complicated by COVID\u201019 was strongly associated with moderate II or higher (odds ratio [OR]\u2009=\u200910.871,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), antipsychotics (OR\u2009=\u20091.947,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.034), transfer from psychiatric hospitals (OR\u2009=\u20092.878,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006), and older age (\u226565 years, OR\u2009=\u20094.467,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) were significant risk factors for moderate II or higher COVID\u201019. Moderate II or higher COVID\u201019 significantly predicted all\u2010cause mortality (OR\u2009=\u200932.658,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). Phase\u2010stratified analyses indicated that older age (Phase 2: OR 3.69; Phase 3: OR 4.75) and aspiration pneumonia (Phase 3: OR 13.9) were consistently associated with moderate II or higher COVID\u201019, whereas the association with antipsychotic use was phase\u2010dependent (significant in Phase 2: OR 4.74, but not in Phase 3: OR 1.12).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that patients with psychiatric disorders, particularly elderly individuals or those with aspiration pneumonia, are associated with moderate II or higher COVID\u201019. Further prospective observational studies are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pcn5.70230","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T07:45:44Z","timestamp":1762415144000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A retrospective risk factor analysis in psychiatric inpatients with COVID\u201019 from 2020 to 2023 at a neuropsychiatric hospital in Tokyo"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6147-5008","authenticated-orcid":false,"given":"Takuma","family":"Inagawa","sequence":"first","affiliation":[{"name":"Department of Psychiatry, National Center of Neurology and Psychiatry Hospital National Center of Neurology and Psychiatry Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Ariga","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, National Center of Neurology and Psychiatry Hospital National Center of Neurology and Psychiatry Tokyo Japan"},{"name":"Home Medical Care Unit, Okada Clinic Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Okano","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, National Center of Neurology and Psychiatry Hospital National Center of Neurology and Psychiatry Tokyo Japan"},{"name":"Department of Psychiatry Fukushima Medical Center of Mental Health Fukushima Japan"},{"name":"Department of Behavioral Medicine, National Center of Neurology and Psychiatry National Institute of Mental Health Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takako","family":"Enokida","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, National Center of Neurology and Psychiatry Hospital National Center of Neurology and Psychiatry Tokyo Japan"},{"name":"Department of Bioresources, Medical Genome Center National Center of Neurology and Psychiatry Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2286-8663","authenticated-orcid":false,"given":"Takashi","family":"Usami","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, National Center of Neurology and Psychiatry Hospital National Center of Neurology and Psychiatry Tokyo Japan"},{"name":"Department of Psychiatry Fukuoka Prefectural Psychiatry Center Dazaifu Hospital Fukuoka Japan"},{"name":"Department of Drug Dependence Research, National Center of Neurology and Psychiatry National Institute of Mental Health Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Unuma","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Center of Neurology and Psychiatry Hospital National Center of Neurology and Psychiatry Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Saitoh","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Center of Neurology and Psychiatry Hospital National Center of Neurology and Psychiatry Tokyo Japan"},{"name":"Department of Neurology Tokyo Metropolitan Neurological Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Satake","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, National Center of Neurology and Psychiatry Hospital National Center of Neurology and Psychiatry Tokyo Japan"},{"name":"National Institute for Health Crisis Management Chiba Japan to National Institute for Health Crisis Management Chiba Japan"},{"name":"Department of Community Mental Health and Law, National Center of Neurology and Psychiatry National Institute of Mental Health Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takamasa","family":"Noda","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, National Center of Neurology and Psychiatry Hospital National Center of Neurology and Psychiatry Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,5]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12297"},{"key":"e_1_2_13_3_1","unstructured":"Tokyo Metropolitan Government Bureau of Social Welfare and Public Health. 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