{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T15:11:05Z","timestamp":1771168265711,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PCN Reports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Celiac disease (CD) is an autoimmune\u2010mediated systemic disorder triggered by the ingestion of gluten. While it typically presents with gastrointestinal symptoms, it is also associated with various neuropsychiatric manifestations, including depression, migraine, developmental disorders, and epilepsy. In Asia, particularly in Japan, CD remains underdiagnosed, potentially delaying appropriate diagnosis and treatment for early intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>We report the case of a 16\u2010year\u2010old girl who presented with long\u2010standing behavioral issues, including repeated theft and rule violations since elementary school. She was diagnosed with attention\u2010deficit\/hyperactivity disorder (ADHD), conduct disorder, and oppositional defiant disorder, but responded poorly to psychiatric treatment. In light of her coexisting physical symptoms, including chronic gastrointestinal complaints and unexplained laboratory abnormalities, further evaluation, including a duodenal biopsy, was conducted. The diagnosis of CD was confirmed, and a gluten\u2010free diet was initiated. Following dietary intervention, both her psychiatric and physical symptoms improved significantly, and no recurrence was observed during follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case highlights the importance of considering CD as a differential diagnosis in adolescents with treatment\u2010resistant psychiatric symptoms, especially when accompanied by physical signs suggestive of systemic disease. Early recognition and intervention with a gluten\u2010free diet may improve both psychiatric and physical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pcn5.70267","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T09:14:13Z","timestamp":1765530853000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A case of celiac disease carrying the half DQ2 variant with a variety of psychiatric manifestations"],"prefix":"10.1002","volume":"4","author":[{"given":"Akiko","family":"Sato","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry, School of Medicine Fukushima Medical University Fukushima Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1569-7819","authenticated-orcid":false,"given":"Yasuto","family":"Kunii","sequence":"additional","affiliation":[{"name":"Department of Disaster Psychiatry, International Research Institute of Disaster Science Tohoku University Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Tsunoda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Aizu\u2010nishi Hospital Aizuwakamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiko","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Pathology Takeda General Hospital  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Osonoe","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Takeda General Hospital  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuzo","family":"Hoshino","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Takeda General Hospital  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"GeneReviews [Internet]","author":"Taylor AK","year":"2008"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301346"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10101445"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1087054716669589"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12664-021-01215-2"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12010142"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.05.040"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2008.10.018"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10070875"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032075"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v27.i19.2251"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgh3.12352"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2019.11.009"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232415564"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002407"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10070875"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/children9060781"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.148.5.564"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954422416000214"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40337-020-00312-5"},{"key":"e_1_2_12_22_1","doi-asserted-by":"crossref","unstructured":"GrauA Magallon\u2010NeriE FausG FeixasG.Cognitive impairment in eating disorder patients of short and long\u2010term duration: a case\u2010control study. 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