{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T12:20:42Z","timestamp":1784204442284,"version":"3.55.0"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PCN Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This randomized controlled trial aims to examine the effects of an internet\u2010delivered compassion\u2010focused therapy program on depressive symptoms in women with recurrent pregnancy loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The target population will be non\u2010pregnant women aged 18\u201350 years with at least two pregnancy losses who visit the recurrent pregnancy loss outpatient clinics. Participants who fulfill the eligibility criteria will be randomly assigned to either a 5\u2010week intervention group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200955) or a waitlist control group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200955). Participants in the intervention group will be asked to complete four weekly video modules (20\u201325\u2009min each), including psychoeducation, experiential exercises, and homework assignments based on compassion\u2010focused therapy principles. The intervention incorporates psychiatrist\u2010guided support through weekly messages encouraging participants to share insights and questions about the program. The primary outcome is depression severity measured by the Patient Health Questionnaire\u20109. Secondary outcomes are psychological distress, perinatal grief, self\u2010compassion, rumination, and worry about future pregnancies. Assessments will be conducted at baseline, 5\u2010week follow\u2010up (post\u2010intervention), and 13\u2010week follow\u2010up. Mixed model analyses will be conducted to test the effectiveness of the intervention.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>As this is a study protocol, results are not yet available.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>If the intervention program demonstrates significant benefits, it could be offered to all women with recurrent pregnancy loss in Japan.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pcn5.70293","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T10:36:13Z","timestamp":1773916573000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Guided internet\u2010delivered compassion\u2010focused therapy 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