{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T05:50:30Z","timestamp":1774590630371,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["T21K157300"],"award-info":[{"award-number":["T21K157300"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PCN Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Living alone and loneliness are recognized risk factors for neuropsychiatric symptoms in older adults. However, the distinct of the objective condition of living alone and subjective loneliness on specific neuropsychiatric symptoms in individuals with mild cognitive impairment (MCI) remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective study, we analyzed data from 312 older adults with MCI (74 living alone and 238 living with family) who attended a university psychiatry clinic. Neuropsychiatric symptoms and subjective loneliness were assessed using the Neuropsychiatric Inventory and the UCLA Loneliness Scale, respectively. Living arrangement (living alone vs. living with family) was recorded. Negative binomial regression with a log link function examined associations of depression, anxiety, delusions, and hallucinations with living alone and loneliness, adjusting for potential confounders. Furthermore, sensitivity analyses were performed by excluding variables with highly unbalanced distributions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients living alone showed significantly higher delusions, hallucinations, and disinhibition scores than those living with family, whereas apathy scores were significantly lower. Multivariate analyses showed that loneliness, but not living alone, was significantly associated with depression and anxiety. Delusions were significantly associated with both loneliness and living alone. In contrast, no significant associations were found between hallucinations and either living alone or loneliness. The significant associations for all neuropsychiatric symptoms were maintained in the sensitivity analysis, except for hallucinations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Neuropsychiatric symptoms in individuals with MCI show differential associations with loneliness and living alone. These findings suggest that useful non\u2010pharmacological interventions may differ depending on the symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pcn5.70299","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T10:36:28Z","timestamp":1770719788000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations of living alone and loneliness with neuropsychiatric symptoms in individuals with mild cognitive impairment: A retrospective cross\u2010sectional study"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5686-4084","authenticated-orcid":false,"given":"Kayo","family":"Takeda","sequence":"first","affiliation":[{"name":"Department of Psychiatry The University of Osaka Graduate School of Medicine Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3662-1469","authenticated-orcid":false,"given":"Hideki","family":"Kanemoto","sequence":"additional","affiliation":[{"name":"Department of Psychiatry The University of Osaka Graduate School of Medicine Suita Osaka Japan"},{"name":"Health and Counseling Center The University of Osaka Toyonaka Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Suehiro","sequence":"additional","affiliation":[{"name":"Department of Psychiatry The University of Osaka Graduate School of Medicine Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9350-3162","authenticated-orcid":false,"given":"Yuto","family":"Satake","sequence":"additional","affiliation":[{"name":"Department of Psychiatry The University of Osaka Graduate School of Medicine Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiki","family":"Taomoto","sequence":"additional","affiliation":[{"name":"Department of Psychiatry The University of Osaka Graduate School of Medicine Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7289-7818","authenticated-orcid":false,"given":"Shigeki","family":"Katakami","sequence":"additional","affiliation":[{"name":"Department of Psychiatry The University of Osaka Graduate School of Medicine Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Yoshiyama","sequence":"additional","affiliation":[{"name":"Department of Psychiatry The University of Osaka Graduate School of Medicine Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Psychiatry The University of Osaka Graduate School of Medicine Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,10]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"Cabinet Office Japan. Cabinet Office Government of Japan. Annual report on the ageing society FY2024.2024[cited 2024 Dec 26]. Available from:https:\/\/www8.cao.go.jp\/kourei\/whitepaper\/w-2024\/zenbun\/06pdf_index.html"},{"key":"e_1_2_12_3_1","unstructured":"Department of Epidemiology and Public Health Graduate School of Medical Sciences Kyushu University. Research on the prevalence of dementia and mild cognitive impairment and future projections: Ninchish\u014d oyobi keidoninchi\u2010sh\u014dgai no y\u016bby\u014dritsu\u2010ch\u014dsa narabini sh\u014drai suikei ni kansuru kenky\u016b. Article in Japanese [Internet] [cited2025Jun 4]. 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