{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T05:49:46Z","timestamp":1774590586020,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PCN Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This scoping review mapped the existing literature on the application of asenapine for delirium management in patients with cancer, including prevention and treatment, while summarizing current research trends. The review followed the methodological framework proposed by Arksey and O'Malley and was reported in accordance with the Preferred Reporting Items for Systematic reviews and Meta\u2010Analyses Extension for Scoping Reviews. PubMed and Ichushi\u2010Web were searched on June 30, 2025, using the keywords \u201casenapine,\u201d \u201cdelirium,\u201d and \u201ccancer.\u201d Eligible studies included reports on asenapine management for delirium in patients with cancer. Two reviewers independently screened records and extracted data. Among the six records identified, three studies met the inclusion criteria and were included in this review. Two of these were retrospective observational studies, and one was a case report. One retrospective study described six terminally ill patients treated with sublingual asenapine, showing marked improvement in agitation, as measured using the Richmond Agitation\u2010Sedation Scale. The other study analyzed 20 patients with advanced cancer and reported reductions in the Agitation Distress Scale scores, particularly among those with poor performance status. Moreover, this case report highlighted the successful use of sublingual asenapine in a patient with aphagia unresponsive to other antipsychotic agents. Across the studies, asenapine was generally well\u2010tolerated, with one suspected dysarthria and no serious adverse events. The current evidence is limited in quantity and quality, and no preventive studies were identified. While preliminary findings suggest that sublingual asenapine may be useful and well\u2010tolerated for treating delirium in patients with cancer, further high\u2010quality studies are warranted.<\/jats:p>","DOI":"10.1002\/pcn5.70307","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:13:52Z","timestamp":1773011632000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Asenapine for delirium in patients with cancer: A scoping review"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8513-2373","authenticated-orcid":false,"given":"Tetsuro","family":"Ishida","sequence":"first","affiliation":[{"name":"Delirium Subcommittee, Guideline Development Committee Japan Psycho\u2010Oncology Society Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Kobayakawa","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Hiroshima Red Cross Hospital &amp; Atomic\u2010Bomb Survivors Hospital Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Kako","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine Mie University Tsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinobu","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Internal Medicine NHO Kinki Chuo Chest Medical Center Sakai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoichi","family":"Sadahiro","sequence":"additional","affiliation":[{"name":"Department of Psycho\u2010Oncology, National Cancer Center Hospital National Cancer Center Japan Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Tanimukai","sequence":"additional","affiliation":[{"name":"Graduate School of Nursing Nagoya City University Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra052321"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.6.786"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.43.3.183"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2008.885"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2024.07.022"},{"key":"e_1_2_13_8_1","volume-title":"Delirium in Cancer Patients: JPOS\u2010JASCC Clinical Practice Guidelines","author":"Japan Psycho\u2010Oncology Society; Japanese Association of Supportive Care in Cancer","year":"2025"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu238"},{"key":"e_1_2_13_10_1","unstructured":"National Comprehensive Cancer Network (NCCN).NCCN clinical practice guidelines in oncology: palliative care version 2.2025. 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