{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T05:50:43Z","timestamp":1774590643145,"version":"3.50.1"},"reference-count":65,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PCN Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Significant, positive correlations between internet gaming disorder (IGD) and autism spectrum disorder (ASD) are known. Individuals with ASD are prone to problematic internet use due to addiction or restricted interests. Here, we examined cortical neural activity in individuals with IGD comorbid with ASD during a gaming\u2010related cue reactivity task, using magnetoencephalography (MEG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>MEG was used to record neural activity in right\u2010handed male participants aged 11\u201320 years (11 IGD\u2013ASD, 13 healthy controls; intelligence quotient [IQ] \u2265 80). IGD and ASD were diagnosed per DSM\u20105\u2010TR criteria. During MEG recording, participants viewed gaming cues and neutral base stimuli in a cue reactivity task. Source\u2010level cortical activity was estimated using minimum norm estimation (MNE), and statistical comparisons were performed using two\u2010tailed nonparametric permutation tests with false discovery rate (FDR) correction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the IGD\u2013ASD group, neural activity was significantly elevated at 137 ms in the right fusiform gyrus during gaming cues compared with the base condition (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.000039). Between\u2010group comparisons under cue conditions (200\u2013270 ms) showed higher right frontal activation (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.0028) and lower activation in left lateral occipital (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.000092), fusiform (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.00025), lingual (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.0017), and parahippocampal regions (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.000049) in the IGD\u2013ASD group compared with controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The IGD\u2013ASD group showed increased right frontal activity and decreased left occipital, fusiform, lingual, and parahippocampal activity during exposure to the gaming cue, suggesting atypical visual and cognitive processing mechanisms in this comorbid group. Further studies comparing individuals with ASD and those with IGD\u2013ASD, as well as by examining the neurophysiological characteristics of individuals with ASD who develop or recover from IGD, might clarify the pathology of these populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pcn5.70312","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T09:29:47Z","timestamp":1773653387000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Atypical cortical neural activity in internet gaming disorder comorbid with autism spectrum disorder during a cue reactivity task: A magnetoencephalography study"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0982-618X","authenticated-orcid":false,"given":"Faisal Budisasmita Paturungi","family":"Parawansa","sequence":"first","affiliation":[{"name":"Department of Psychiatry Niigata University 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