{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T09:50:43Z","timestamp":1782467443642,"version":"3.54.5"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PCN Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Clozapine is an atypical antipsychotic that is highly effective in managing treatment\u2010resistant schizophrenia. However, its use is associated with a wide range of adverse effects, including agranulocytosis, seizures, sedation, and gastrointestinal issues such as constipation, and less commonly, diarrhea. While constipation is a well\u2010documented side effect of clozapine, diarrhea induced by the drug remains underreported and poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>A 46\u2010year\u2010old male patient with treatment\u2010resistant schizophrenia developed severe diarrhea, fever, and weight loss shortly after initiating clozapine at a dose of 100\u2009mg three times daily (300\u2009mg\/day). These symptoms persisted until clozapine was discontinued, after which they resolved. When clozapine was reintroduced, the symptoms of diarrhea recurred, confirming that clozapine was the causative agent of the gastrointestinal distress. The patient's clinical condition improved once clozapine was discontinued again, highlighting the potential for severe gastrointestinal adverse effects associated with this medication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Clozapine remains a valuable treatment option for individuals with treatment\u2010resistant schizophrenia, but clinicians should be aware of its potential to cause severe gastrointestinal adverse effects, including diarrhea. Early recognition of these side effects, appropriate diagnostic evaluation, and timely management are essential to ensure patient safety and optimize treatment outcomes. In cases where gastrointestinal symptoms are severe, discontinuation of clozapine may be necessary to resolve the issues and prevent further complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pcn5.70318","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T10:36:03Z","timestamp":1779964563000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clozapine\u2010induced diarrhea: A case report and mechanistic overview"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7579-2227","authenticated-orcid":false,"given":"Shahab","family":"Dastmardi","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soha","family":"Namazi","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy School of Pharmacy Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000001204"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/10401230309085668"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.schbul.a033333"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psycr.2022.100070"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e31825de1dd"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/indianjpsychiatry_1196_24"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/jcp.0b013e31815a257f"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-018-0587-4"},{"issue":"4","key":"e_1_2_12_10_1","article-title":"Gastrointestinal complications of clozapine treatment: assessment and management","volume":"27","author":"Perez JH","year":"2025","journal-title":"Prim Care Companion CNS Disord"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1253156"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.7.1386-a"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2012-007933"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1586\/eci.11.34"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000002003"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.2019.267"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.13450"}],"container-title":["Psychiatry and Clinical Neurosciences Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pcn5.70318","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pcn5.70318","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pcn5.70318","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T09:45:06Z","timestamp":1782467106000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pcn5.70318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,28]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/pcn5.70318"],"URL":"https:\/\/doi.org\/10.1002\/pcn5.70318","archive":["Portico"],"relation":{},"ISSN":["2769-2558","2769-2558"],"issn-type":[{"value":"2769-2558","type":"print"},{"value":"2769-2558","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,28]]},"assertion":[{"value":"2025-12-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70318"}}