{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T07:51:18Z","timestamp":1791532278302,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PCN Reports"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Systemic inflammation\u2010associated acute brain dysfunction, typified by delirium, is linked to later cognitive impairment. Although trazodone is used clinically for delirium\u2010related symptoms, its effects on subsequent cognition remain unclear. We examined whether acute\u2010phase trazodone treatment influences behavioral abnormalities, later cognitive outcomes, and inflammatory\/glial\u2010related changes in an lipopolysaccharide (LPS)\u2010induced mouse model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult male C57BL\/6J mice received saline or LPS (3.0\u2009mg\/kg, intraperitoneally). Control mice received saline, whereas LPS\u2010treated mice subsequently received saline or trazodone (10\u2009mg\/kg, subcutaneously). In addition to a group receiving trazodone during the acute phase (Days 0\u20132), a group receiving trazodone for 7 days was also included. Behavioral assessments were performed on Day 1 (acute phase), Day 3 (recovery phase), and Day 7 (postrecovery phase) using nesting, open\u2010field, Y\u2010maze, and novel object recognition tests. Plasma cytokines and inflammatory and glial markers in the cerebral cortex and hippocampus were also assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During the acute phase, trazodone\u2010treated LPS mice showed reduced locomotor activity, whereas stimulus\u2010dependent exploratory behavior and nesting were relatively preserved. During the recovery phase, novel object recognition performance was better in trazodone\u2010treated than in saline\u2010treated LPS mice. Elevations of cortical Iba1 and IL\u20106 and hippocampal GFAP during the acute phase were evident in saline\u2010treated LPS mice but not clearly in trazodone\u2010treated LPS mice. Direct comparison between the two trazodone regimens showed no clear additional benefit of continued treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this model, acute\u2010phase trazodone treatment was associated with milder acute behavioral abnormalities and better subsequent short\u2010term\u2010memory performance, whereas the benefit of continued treatment remained uncertain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pcn5.70426","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T07:41:07Z","timestamp":1791531667000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute trazodone treatment ameliorates behavioral abnormalities and improves subsequent short\u2010term memory in a lipopolysaccharide\u2010induced mouse model of acute brain 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