{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T11:46:02Z","timestamp":1792410362598,"version":"4.4.0"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PCN Reports"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Treatment of depression in patients with cancer requires individualized decision\u2010making considering physical symptoms, drug interactions, adverse effects, treatment burden, and acceptability. We report a patient with persistent depression after colorectal cancer treatment, in whom pharmacotherapy was constrained by insufficient efficacy and tolerability, improvement with modified electroconvulsive therapy (mECT) was temporary, and reintroduction of mECT was difficult. She subsequently received repetitive transcranial magnetic stimulation (rTMS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>A woman in her 60s developed depression after emergency surgery for lower gastrointestinal perforation caused by descending colon cancer and later developed chemotherapy\u2010induced peripheral neuropathy (CIPN) after postoperative chemotherapy. Pharmacotherapy produced insufficient improvement. Although 10 mECT sessions led to improvement, symptoms recurred after discharge. Reintroduction of mECT was not possible because of strong fear of the treatment and general anesthesia. She was referred to our hospital and received 27 rTMS sessions without changes in psychotropic medication. Her 17\u2010item Hamilton Depression Rating Scale and Clinical Global Impressions\u2013Severity (CGI\u2010S) scores improved from 19 to 8 and from 4 to 1, respectively, whereas the pain Numerical Rating Scale score remained 8. Behavior and daily functioning also improved. Six months after treatment, limb discomfort persisted, but she could still perform household chores and go out. The referring physician rated the CGI\u2010S score as 1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>When pharmacotherapy for depression after cancer treatment is constrained by insufficient efficacy or tolerability, and the benefit of mECT is transient or its reintroduction is difficult, rTMS may be considered as a treatment option.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pcn5.70431","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T11:16:28Z","timestamp":1792408588000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Repetitive transcranial magnetic stimulation for depression after colorectal cancer treatment with chemotherapy\u2010induced peripheral neuropathy: A case report"],"prefix":"10.1002","volume":"5","author":[{"given":"Kosei","family":"Esaki","sequence":"first","affiliation":[{"name":"Department of Psychiatry Fujita Health University School of Medicine Toyoake Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeo","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Fujita Health University School of Medicine Toyoake Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7312-1266","authenticated-orcid":false,"given":"Yuki","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Development and Education of Clinical Research Fujita Health University School of Medicine Toyoake Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueren","family":"Zhao","sequence":"additional","affiliation":[{"name":"Faculty of Nursing, School of Health Sciences Fujita Health University Toyoake Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Kitajima","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Fujita Health University School of Medicine Toyoake Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nakao","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Fujita Health University School of Medicine Toyoake Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,19]]},"reference":[{"issue":"2","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/pon.3409","article-title":"Prevalence of depression in cancer patients: a meta\u2010analysis of diagnostic interviews and self\u2010report instruments","volume":"23","author":"Krebber AMH","year":"2014","journal-title":"Psycho\u2010Oncol"},{"issue":"12","key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1002\/cncr.31369","article-title":"Symptoms of anxiety and depression among colorectal cancer survivors from the population\u2010based, longitudinal PROFILES Registry: Prevalence, predictors, and impact on quality of life","volume":"124","author":"Mols F","year":"2018","journal-title":"Cancer"},{"issue":"5","key":"e_1_2_12_4_1","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1097\/PSY.0000000000000942","article-title":"Major depression and survival in people with cancer","volume":"83","author":"Walker J","year":"2021","journal-title":"Psychosom Med"},{"issue":"2","key":"e_1_2_12_5_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.esmoop.2023.101155","article-title":"Anxiety and depression in adult cancer patients: ESMO Clinical Practice Guideline","volume":"8","author":"Grassi L","year":"2023","journal-title":"ESMO Open"},{"issue":"12","key":"e_1_2_12_6_1","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1007\/s40261-020-00976-6","article-title":"Treatment of major depressive disorder in Japanese patients with cancer: a matched cohort study using employer\u2010based health insurance claims data","volume":"40","author":"Akechi T","year":"2020","journal-title":"Clin Drug Invest"},{"issue":"3","key":"e_1_2_12_7_1","first-page":"011006","article-title":"Antidepressants for the treatment of depression in people with cancer","volume":"3","author":"Vita G","year":"2023","journal-title":"Cochr Database Syst Rev"},{"issue":"2","key":"e_1_2_12_8_1","doi-asserted-by":"crossref","first-page":"258","DOI":"10.4103\/indianjpsychiatry.indianjpsychiatry_491_22","article-title":"Clinical practice guidelines for the use of electroconvulsive therapy","volume":"65","author":"Thirthalli J","year":"2023","journal-title":"Indian J Psychiatry"},{"key":"e_1_2_12_9_1","doi-asserted-by":"crossref","DOI":"10.1177\/20451253211042696","article-title":"Repetitive transcranial magnetic stimulation for major depressive disorder: basic principles and future directions","volume":"11","author":"Miron JP","year":"2021","journal-title":"Ther Adv Psychopharmacol"},{"issue":"1","key":"e_1_2_12_10_1","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1186\/s12888-023-05033-y","article-title":"Efficacy of repetitive transcranial magnetic stimulation (rTMS) adjunctive therapy for major depressive disorder (MDD) after two antidepressant treatment failures: meta\u2010analysis of randomized sham\u2010controlled trials","volume":"23","author":"Vida RG","year":"2023","journal-title":"BMC Psychiatry"},{"issue":"4","key":"e_1_2_12_11_1","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1177\/02692163241234799","article-title":"Accelerated transcranial magnetic stimulation for psychological distress in advanced cancer: a phase 2a feasibility and preliminary efficacy clinical trial","volume":"38","author":"Downar J","year":"2024","journal-title":"Palliat Med"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0000000000001290"},{"key":"e_1_2_12_13_1","unstructured":"Japanese Society of Psychiatry and Neurology Guidelines for the appropriate use of repetitive transcranial magnetic stimulation devices. Japanese Society of Psychiatry and Neurology;2023.https:\/\/www.jspn.or.jp\/uploads\/uploads\/files\/activity\/Guidelines_for_appropriate_use_of_rTMS_202309.pdf"},{"issue":"2","key":"e_1_2_12_14_1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1001\/jamapsychiatry.2016.3644","article-title":"Repetitive transcranial magnetic stimulation for the acute treatment of major depressive episodes: a systematic review with network meta\u2010analysis","volume":"74","author":"Brunoni AR","year":"2017","journal-title":"JAMA Psychiatry"},{"issue":"7","key":"e_1_2_12_15_1","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1002\/da.22060","article-title":"Efficacy and acceptability of high frequency repetitive transcranial magnetic stimulation (rTMS) versus electroconvulsive therapy (ECT) for major depression: a systematic review and meta\u2010analysis of randomized trials: review: high frequency rTMS versus ECT for major depression","volume":"30","author":"Berlim MT","year":"2013","journal-title":"Depress Anxiety"}],"container-title":["Psychiatry and Clinical Neurosciences Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pcn5.70431","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pcn5.70431","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pcn5.70431","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T11:16:30Z","timestamp":1792408590000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pcn5.70431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,19]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["10.1002\/pcn5.70431"],"URL":"https:\/\/doi.org\/10.1002\/pcn5.70431","archive":["Portico"],"relation":{},"ISSN":["2769-2558","2769-2558"],"issn-type":[{"value":"2769-2558","type":"print"},{"value":"2769-2558","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,19]]},"assertion":[{"value":"2026-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70431"}}