{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:05:18Z","timestamp":1753869918200,"version":"3.41.2"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T00:00:00Z","timestamp":1674691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012319","name":"National Center for Global Health and Medicine","doi-asserted-by":"publisher","award":["19A1026"],"award-info":[{"award-number":["19A1026"]}],"id":[{"id":"10.13039\/100012319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["PCN Reports"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Hyponatremia is a common electrolyte disorder. The severe hyponatremia has a mortality rate of 4%\u201340%. Psychiatric patients are likely to develop the condition because of polydipsia or the adverse effects of antipsychotics. We investigated the characteristics of patients with and without psychiatric diseases who developed severe hyponatremia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We retrospectively investigated cases admitted to our hospital (all departments) between October 2012 and November 2015 with a serum sodium concentration of \u2264125\u2009mmol\/l on admission. We compared patient characteristics, etiology, and clinical course between psychiatric and nonpsychiatric patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 123 cases (62 female) were analyzed. Psychiatric disorders were present in 69 cases (56%), including schizophrenia (<jats:italic>n<\/jats:italic>\u2009=\u200919), anorexia (<jats:italic>n<\/jats:italic>\u2009=\u200916), mood disorders (<jats:italic>n<\/jats:italic>\u2009=\u200914), and organic mental disorders (<jats:italic>n<\/jats:italic>\u2009=\u20099). The mean patient age was 63 years. The mean serum sodium concentration on admission was 119\u2009mmol\/l, and the main causes of hyponatremia were polydipsia (20%), insufficient sodium intake (18%), and syndrome of inappropriate antidiuretic hormone secretion (16%). Compared with the nonpsychiatric group, the psychiatric group was significantly younger (55 vs. 74 years), was more likely to have polydipsia (30% vs. 6%), and had a lower in\u2010hospital mortality (0% vs. 17%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study found differences in the clinical picture between psychiatric and nonpsychiatric patients with severe hyponatremia. Clinicians need to monitor serum sodium because the symptoms of hyponatremia can mimic those of psychiatric diseases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pcn5.77","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T06:48:44Z","timestamp":1674802124000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of severe hyponatremia in patients with and without psychiatric diseases: A single\u2010center retrospective study"],"prefix":"10.1002","volume":"2","author":[{"given":"Eriko","family":"Makino","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Kohnodai Hospital National Center for Global Health and Medicine Ichikawa Chiba Japan"},{"name":"Department of Psychiatry, Kohnodai Hospital National Center for Global Health and Medicine Ichikawa Chiba 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