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Prior to treatment, diagnosis must take into account the differentiation from, and comorbidity with, organic brain diseases such as dementia and delirium, as well as depression caused by other physical diseases or medications. As clinical features of LLD, treatment response tends to be poor in older patients and recurrence rates are higher than those in early adult patients, therefore psycho\u2010social interventions on the basis of the patient's background and condition are important for LLD. The first\u2010line treatment strategy generally depends on the severity of the depression. Systematic psychotherapies, including cognitive behavioral therapy and problem\u2010solving therapy, have been reported to reduce depressive symptoms in LLD. Regarding pharmacotherapy, newer antidepressants are recommended for LLD, but careful attention to adverse events is required. Treatment using neuromodulation is also reported to be useful for LLD. In the current review, for further\u2010line treatment, treatment strategies were divided according to the level of first\u2010line treatment response. Evidence indicates that LLD is more heterogeneous than depression in younger adults, therefore when treating LLD patients it is necessary to take various conditions and situations into consideration, and to provide detailed treatment that is tailored to each patient.<\/jats:p>","DOI":"10.1002\/pcn5.91","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T04:00:24Z","timestamp":1683518424000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Treatment strategy for late\u2010life depression"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9678-8776","authenticated-orcid":false,"given":"Hajime","family":"Baba","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, Juntendo Koshigaya Hospital Juntendo University Saitama Japan"},{"name":"Department of Psychiatry &amp; Behavioral Science Juntendo University Graduate School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,7]]},"reference":[{"key":"e_1_2_14_2_1","unstructured":"Guidelines for Treatment of Late\u2010life Depression (Japanese).A committee for treatment guidelines of mood disorders of the Japanese Society of Mood Disorders. 2022 [cited 2023 Jan 23]. 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London: National Institute for Health and Care Excellence: Guidelines;2022."},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.2017.28"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00308-6"},{"issue":"9","key":"e_1_2_14_21_1","article-title":"Continuation and maintenance treatments for depression in older people","volume":"9","author":"Wilkinson P","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e3181ec8085"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.5706"}],"container-title":["Psychiatry and Clinical Neurosciences Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pcn5.91","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T13:48:50Z","timestamp":1705758530000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pcn5.91"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,7]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1002\/pcn5.91"],"URL":"https:\/\/doi.org\/10.1002\/pcn5.91","archive":["Portico"],"relation":{},"ISSN":["2769-2558","2769-2558"],"issn-type":[{"value":"2769-2558","type":"print"},{"value":"2769-2558","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,7]]},"assertion":[{"value":"2023-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e91"}}