{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T16:58:03Z","timestamp":1758473883660},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2001,8,2]],"date-time":"2001-08-02T00:00:00Z","timestamp":996710400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2001,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of the present study was to assess the value of biometric lung measurements for the diagnosis of severe fetal pulmonary hypoplasia by investigating whether a significant correlation between two\u2010dimensional lung biometry measurements and autopsy findings could be established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective study carried out between 1995 and 1997. Nomograms for normal fetuses of the arterior\u2013posterior and transverse inner thoracic diameters, which describe the growth and shape of the lung, were used as a basis for diagnosis of pulmonary hypoplasia in fetuses at high risk of developing the condition (the fetuses had bilateral renal agenesis or multicystic kidneys; chronic PROM &lt;25 gestational weeks or hydrothorax). Pregnancy was terminated by abortion or intrauterine death in 29\/43 high\u2010risk fetuses and autopsies were performed. Only the 29 fetuses for which there were autopsy findings were included in the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The best plane for diagnosing pulmonary hypoplasia was the four\u2010chamber view. The diagnostic accuracy for this view as expressed by the sensitivity was 57% for the anterior\u2013posterior diameter and 44% for the transverse diameter; as expressed by the specificity it was 42% for the anterior\u2013posterior diameter and 50% for the transverse diameter. The results for the four\u2010chamber view for the various high\u2010risk conditions were as follows: for fetuses with chronic PROM we obtained sensitivities of 75% and 50% (anterior\u2013posterior and transverse dimensions, respectively) and specificities of 80% and 60% (anterior\u2013posterior and transverse dimensions, respectively). The sensitivities of lung biometry in fetuses with hydrothorax were 1% and 80% for the two diameters, but there was a low specificity. In fetuses with bilateral renal agenesis or multicystic kidneys we obtained sensitivities of 36% and 30% (anterior\u2013posterior and transverse dimensions, respectively) and a specificity of 50% (anterior\u2013posterior dimension).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The pesent results show that two\u2010dimensional lung biometry is not a suitable method for antenatal detection of pulmonary hypoplasia. However, in individual cases with high risk for pulmonary hypoplasia, lung biometry might prove to be an additional diagnostic parameter. 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