{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:27:59Z","timestamp":1792740479592,"version":"4.5.0"},"reference-count":56,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2004,12,21]],"date-time":"2004-12-21T00:00:00Z","timestamp":1103587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2004,12,30]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The detailed study of the fetal cardiac anatomy in the first trimester of pregnancy by means of ultrasound, transvaginally or transabdominally, is feasible and remains a safe procedure provided thermal and mechanical indices are taken into account. Optimal time for successful imaging of the four chambers and great arteries in early gestation appears to be between 13 to 14 weeks. In experienced hands, first\u2010trimester fetal echocardiography is accurate in detecting major structural cardiac abnormalities and yields a high negative predictive value. Thus, in a clinical setting, it can be offered to families considered to be \u2018at risk\u2019 of cardiac defects (e.g. those with previous family history or when fetal nuchal translucency is increased) and can be a powerful tool to reassure families regarding normality of major cardiac structures and connections. However, the early detection of an important structural abnormality (chromosomally normal or not) may be associated with a high termination rate if this is an acceptable option. The high prevalence of associated chromosomal and extracardiac abnormalities for many of the high\u2010risk families, who may benefit from this approach, cannot be ignored. Therefore, fetal heart scanning in the first trimester should be performed in conjunction with detailed first\u2010trimester obstetric scanning. Copyright \u00a9 2004 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/pd.1063","type":"journal-article","created":{"date-parts":[[2004,12,21]],"date-time":"2004-12-21T15:53:48Z","timestamp":1103644428000},"page":"1060-1067","source":"Crossref","is-referenced-by-count":89,"title":["Fetal heart scanning in the first trimester"],"prefix":"10.1002","volume":"24","author":[{"given":"Julene S.","family":"Carvalho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,12,21]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"69","article-title":"First\u2010trimester diagnosis of fetal congenital heart disease by transvaginal ultrasonography","volume":"84","author":"Achiron R","year":"1994","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1994.13.10.783"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(86)90072-X"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.77.1.68"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.44.4.444"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000020817"},{"key":"e_1_2_1_8_1","volume-title":"Progress in Obstetrics and Gynaecological Sonography Series","author":"Barnett SB","year":"1988"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1999.14050311.x"},{"key":"e_1_2_1_10_1","volume-title":"The embryonic examination. 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