{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T09:21:43Z","timestamp":1778923303441,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,3,24]],"date-time":"2005-03-24T00:00:00Z","timestamp":1111622400000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2005,3]]},"abstract":"Abstract<\/jats:title>Objectives<\/jats:title>To describe the maternal serum marker patterns of triploid pregnancies and estimate the second\u2010trimester prevalence of triploidy.<\/jats:p><\/jats:sec>Methods<\/jats:title>Forty\u2010two cases of triploidy were identified in six serum screening programmes, five in the United Kingdom, one in Canada. This study describes the serum marker patterns, serum screening results for Down syndrome, trisomy 18 and open neural tube defects, and maternal age of these triploidy cases. The risk cut\u2010off levels were \u2265 1 in 250 for Down syndrome, \u22652.5 MoMs alpha\u2010fetoprotein for open neural tube defects and \u22651:100 for trisomy 18 screening. The estimated second\u2010trimester prevalence of triploidy was based on 22 triploidy cases ascertained in 599 934 pregnancies from three routine screening programmes, which attempted complete ascertainment of aneuploidy cases.<\/jats:p><\/jats:sec>Results<\/jats:title>The observed second\u2010trimester rate of triploidy was 0.37 per 10 000 fetuses. Two different serum marker patterns were seen in triploid pregnancies, distinguished from each other by typically very high or very low levels of total hCG or free \u03b2\u2010hCG. The median maternal ages were respectively 33 years for triploidy with human chorionic gonadotrophin levels < 1.0 MoM, and 26 years for those with hCG levels \u22651.0 MoM. Fifty\u2010seven percent of the pregnancies with a triploid fetus had a risk estimate \u22651:100 for trisomy 18 alone, 10% had an alpha\u2010fetoprotein \u22652.5 MoM, 5% were screen positive for Down syndrome alone, and 19% had an increased risk or positive results for more than one anomaly.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The simultaneous use of maternal serum tests designed to screen prenatally for Down syndrome, neural tube defects, and an increased risk of trisomy 18 resulted in a screen\u2010positive result for 90% of pregnancies with triploidy. Copyright \u00a9 2005 John Wiley & Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.1115","type":"journal-article","created":{"date-parts":[[2005,3,24]],"date-time":"2005-03-24T19:18:24Z","timestamp":1111691904000},"page":"229-233","source":"Crossref","is-referenced-by-count":26,"title":["Triploidy identified through second\u2010trimester serum screening"],"prefix":"10.1002","volume":"25","author":[{"given":"Tianhua","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Alberman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Wald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne M.","family":"Summers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,3,24]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.139"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.125240"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199604)16:4<377::AID-PD860>3.0.CO;2-3"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970040704"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.20152"},{"key":"e_1_2_1_7_1","first-page":"139","article-title":"Current management of complete and partial molar pregnancy","volume":"39","author":"Goldstein DP","year":"1994","journal-title":"J Reprod Med"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1982.tb00714.x"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(96)00330-4"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(97)70546-5"},{"key":"e_1_2_1_11_1","first-page":"18","volume-title":"Smith's Recognizable Pattern of human Malformation","author":"Jones KL","year":"1997"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(96)90277-4"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(85)90572-1"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/302951"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.1115","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.1115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T19:53:57Z","timestamp":1700164437000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.1115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["10.1002\/pd.1115"],"URL":"https:\/\/doi.org\/10.1002\/pd.1115","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,3]]}}}