{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T08:55:27Z","timestamp":1766652927355},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2001,7,20]],"date-time":"2001-07-20T00:00:00Z","timestamp":995587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2001,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Obstetric complications, such as severe pre\u2010eclampsia, fetal growth restriction, abruptio placentae, or stillbirth are associated with abnormally elevated second\u2010trimester maternal serum alpha\u2010fetoprotein (MSAFP) and \u03b2 subunit of human chorionic gonadotrophin (\u03b2hCG). This has been attributed to placental abnormalities. Women with thrombophilias have been shown to have abnormalities of the placenta resulting in adverse pregnancy outcome in these patients. The purpose of the present study was to evaluate whether women with pregnancy complications and inherited thrombophilias have abnormally elevated second\u2010trimester MSAFP or \u03b2hCG. Sixty\u2010two women with pregnancy complications were tested for inherited thrombophilias several months after delivery. The thrombophilia group included 29 women with pregnancy complications and an inherited thrombophilia and the control group included 33 other patients without thrombophilia. Patients in the thrombophilia group had a higher median MoM MSAFP compared to the controls (1.337 vs 1.086, <jats:italic>p<\/jats:italic>=0.0516). The incidence of abnormally elevated MSAFP (&gt;2.5\u2009MoM) was also significantly higher in the thrombophilia group compared to controls (21% vs 3%, <jats:italic>p<\/jats:italic>=0.04). Neither the median MoM \u03b2hCG nor the incidence of abnormally elevated \u03b2hCG were significantly different between the groups. We conclude that second trimester MSAFP, but not \u03b2hCG, is abnormally elevated in patients with thrombophilia and obstetric complications. Copyright \u00a9 2001 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/pd.119","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T19:56:46Z","timestamp":1030305406000},"page":"658-661","source":"Crossref","is-referenced-by-count":9,"title":["Second\u2010trimester maternal serum alpha\u2010fetoprotein (MSAFP) iselevated in women with adverse pregnancy outcome associated with inherited thrombophilias"],"prefix":"10.1002","volume":"21","author":[{"given":"Yifat","family":"Ochshorn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Kupferminc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amiram","family":"Eldor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igal","family":"Wolman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph B.","family":"Lessing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuval","family":"Yaron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,7,20]]},"reference":[{"key":"e_1_2_1_2_1","unstructured":"American College of Obstetricians and Gynecologists (ACOG).1991. Alpha\u2010fetoprotein. Technical Bulletin No.\u2009154 April1991.American College of Obstetricians and Gynecologists: Washington DC."},{"key":"e_1_2_1_3_1","unstructured":"American College of Obstetricians and Gynecologists (ACOG).1996. Hypertension in pregnancy. Technical Bulletin No.\u2009219 January1996.American College of Obstetricians and Gynecologists: Washington DC."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(76)90748-1"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1182\/blood.V88.3.877.877","article-title":"Venous thromboembolism associated with double heterozygosity for R506Q mutation of factor V and for T298M mutation of protein C in a large family of a previously described homozygous protein C\u2010deficient newborn with massive thrombosis","volume":"88","author":"Brenner B","year":"1996","journal-title":"Blood"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1982.tb05076.x"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970151108"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0595-111"},{"key":"e_1_2_1_9_1","first-page":"609","volume-title":"Maternal Fetal Medicine: Principles and Practice","author":"Green JR","year":"1994"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-199011000-00001"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(87)80172-2"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901073400102"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(93)90701-J"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"3698","DOI":"10.1182\/blood.V88.10.3698.bloodjournal88103698","article-title":"A genetic variation in the 3\u2032\u2010untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis","volume":"88","author":"Poort SR","year":"1996","journal-title":"Blood"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1983.tb08939.x"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90665-0"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1984.tb04848.x"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(88)90220-7"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)91325-4"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)91333-5"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90392-X"},{"key":"e_1_2_1_22_1","first-page":"150","article-title":"Unexplained elevations of maternal serum alpha\u2010fetoprotein in women with antiphospholipid antibodies: a harbinger of fetal death","volume":"83","author":"Silver RM","year":"1994","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(93)90013-9"},{"key":"e_1_2_1_24_1","first-page":"217","article-title":"An immunopathological study on the placenta in pre\u2010eclampsia","volume":"35","author":"Utoro T","year":"1989","journal-title":"Kobe J Med Sci"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)90953-9"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1985.tb01106.x"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(94)90030-2"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(12)80033-0"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70334-0"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.119","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T17:43:05Z","timestamp":1700415785000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,7,20]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2001,8]]}},"alternative-id":["10.1002\/pd.119"],"URL":"https:\/\/doi.org\/10.1002\/pd.119","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,7,20]]}}}