{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T20:41:51Z","timestamp":1781037711045,"version":"3.54.1"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,6,9]],"date-time":"2006-06-09T00:00:00Z","timestamp":1149811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether first\u2010 and second\u2010trimester Down syndrome screening markers and screen\u2010positive rates are altered in pregnancies conceived using assisted reproductive technologies (ARTs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>ART pregnancies in the multicenter FASTER trial were identified. Marker levels were evaluated for five types of ART: <jats:italic>in vitro<\/jats:italic> fertilization with ovulation induction (IVF\u2010OI), IVF with OI and egg donation (IVF\u2010OI\u2010ED), IVF with ED (IVF\u2010ED), and intrauterine insemination with OI (IUI\u2010OI) or without OI (IUI). Each group was compared to non\u2010ART controls using Mann\u2013Whitney <jats:italic>U<\/jats:italic> analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>First\u2010trimester marker levels were not significantly different between ART and control pregnancies, with the exception of reduced PAPP\u2010A levels in the IUI\u2010OI group. In contrast, second\u2010trimester inhibin A levels were increased in all ART pregnancies, estriol was reduced and human chorionic gonadotropin (hCG) was increased in IVF and IUI pregnancies without ED, and alpha\u2010fetoprotein (AFP) was increased in ED pregnancies. Second\u2010trimester screen\u2010positive rates were significantly higher than expected for ART pregnancies, except when ED was used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These data show that ART significantly impacts second\u2010, but not first\u2010, trimester markers and screen\u2010positive rates. The type of adjustment needed in second\u2010trimester screening depends on the particular type of ART used. Copyright \u00a9 2006 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.1469","type":"journal-article","created":{"date-parts":[[2006,6,9]],"date-time":"2006-06-09T10:31:00Z","timestamp":1149849060000},"page":"672-678","source":"Crossref","is-referenced-by-count":54,"title":["First\u2010 and second\u2010trimester Down syndrome screening markers in pregnancies achieved through assisted reproductive technologies (ART): a FASTER trial study"],"prefix":"10.1002","volume":"26","author":[{"given":"G.","family":"Lambert\u2010Messerlian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Dugoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Vidaver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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