{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T13:55:11Z","timestamp":1780667711978,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2001,8,20]],"date-time":"2001-08-20T00:00:00Z","timestamp":998265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2001,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Placenta growth factor (PIGF), an angiogenic factor belonging to the vascular endothelial growth factor family, pregnancy\u2010associated plasma protein A (PAPP\u2010A) and free \u03b2\u2010human chorionic gonadotrophin (\u03b2\u2010hCG) were measured in maternal serum from 45 pregnancies with trisomy 21, 45 with trisomy 18 and 493 normal controls at 10\u201313 completed weeks of gestation. In the normal pregnancies maternal serum PIGF levels increased exponentially with gestation. The median multiple of the median (MoM) PIGF concentration in the trisomy 21 group (1.26\u2009MoM) was significantly higher (<jats:italic>p<\/jats:italic>&lt;0.0001) than in the control group (1.00\u2009MoM). In the trisomy 18 group the median PIGF was lower (0.889\u2009MoM) but this did not quite reach significance (<jats:italic>p<\/jats:italic>=0.064). The corresponding median MoM values for PAPP\u2010A were 1.00\u2009MoM for the controls, 0.49\u2009MoM for trisomy 21 and 0.16\u2009MoM for trisomy 18. The median MoM values for free \u03b2\u2010hCG were 1.00\u2009MoM for the controls, 2.05\u2009MoM for trisomy 21 and 0.38\u2009MoM for trisomy 18. In the control group there was a small but significant correlation of PIGF with free \u03b2\u2010hCG (<jats:italic>r<\/jats:italic>=+0.1024) and PAPP\u2010A (<jats:italic>r<\/jats:italic>=+0.2288). In the trisomy 18 group there was a significant association between PIGF and free \u03b2\u2010hCG (<jats:italic>r<\/jats:italic>=+0.2629) but not with PAPP\u2010A (<jats:italic>r<\/jats:italic>=+0.0038). In the trisomy 21 group there was a small but significant association with PAPP\u2010A (<jats:italic>r<\/jats:italic>=+0.1028) but not with free \u03b2\u2010hCG (<jats:italic>r<\/jats:italic>=+0.0339). The separation of affected and unaffected pregnancies in maternal serum PIGF is small, and therefore it is unlikely that measurement of PIGF would improve screening for these abnormalities provided by the combination of fetal nuchal translucency and maternal serum PAPP\u2010A and free \u03b2\u2010hCG. Copyright \u00a9 2001 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/pd.148","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T21:23:24Z","timestamp":1030310604000},"page":"718-722","source":"Crossref","is-referenced-by-count":30,"title":["First trimester maternal serum placenta growth factor (PIGF)concentrations in pregnancies with fetal trisomy 21 or trisomy 18"],"prefix":"10.1002","volume":"21","author":[{"given":"Kevin","family":"Spencer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo W.","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charas Y. 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