{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T08:06:28Z","timestamp":1763366788218},"reference-count":12,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,6,5]],"date-time":"2006-06-05T00:00:00Z","timestamp":1149465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Maternal serum ADAM12 is reduced, on average, in early first\u2010trimester Down and Edwards' syndrome pregnancies but the extent of reduction declines with gestation. Here we study levels at 9\u201312 weeks when the marker might be used concurrently with other established markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Samples from 16 Down and 2 Edwards' syndrome cases were retrieved from storage and tested together with 313 unaffected singleton pregnancies using a semi\u2010automated time\u2010resolved immuno\u2010fluorometric assay. Results were expressed in multiples of the gestation\u2010specific median (MoM) based on regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median in Down syndrome was 0.94 MoM with a 10th\u201390th centile range of 0.22\u20131.63 MoM compared with 1.00 and 0.33\u20132.24 MoM in unaffected controls (<jats:italic>P<\/jats:italic> = 0.21, one\u2010side Wilcoxon Rank Sum Test). The two Edwards' syndrome cases had values 0.31 and 2.17 MoM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ADAM12 cannot be used concurrently with other markers in the late first trimester. However, it does have the potential to be used earlier in pregnancy either concurrently with other early markers or in a sequential or contingent protocol. More data will be required to reliably predict the performance of either approach. Copyright \u00a9 2006 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.1480","type":"journal-article","created":{"date-parts":[[2006,6,5]],"date-time":"2006-06-05T10:35:32Z","timestamp":1149503732000},"page":"689-691","source":"Crossref","is-referenced-by-count":47,"title":["Maternal serum ADAM12 levels in Down and Edwards' syndrome pregnancies at 9\u201312 weeks' gestation"],"prefix":"10.1002","volume":"26","author":[{"given":"Jennie","family":"Laigaard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard","family":"Cuckle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulla M.","family":"Wewer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Christiansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,6,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.03.021"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.336"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199910)19:10<905::AID-PD658>3.0.CO;2-Q"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199906)19:6<505::AID-PD572>3.0.CO;2-6"},{"key":"e_1_2_1_6_1","first-page":"795","volume-title":"Genetic Disorders and the Fetus: Diagnosis, Prevention and Treatment","author":"Cuckle H","year":"2004"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.762"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1029"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000165829.65319.65"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.3835"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199702)17:2<101::AID-PD4>3.0.CO;2-H"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/000456320203900604"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199906)19:6<517::AID-PD591>3.0.CO;2-2"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.1480","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.1480","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T19:26:25Z","timestamp":1700076385000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.1480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6,5]]},"references-count":12,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["10.1002\/pd.1480"],"URL":"https:\/\/doi.org\/10.1002\/pd.1480","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6,5]]}}}