{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T01:05:00Z","timestamp":1778893500308,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,7,5]],"date-time":"2006-07-05T00:00:00Z","timestamp":1152057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To present a series of prenatally detected cases of recurrent pericentric inversions with euchromatic breakpoints and to review the literature to determine whether parental karyotyping is required for genetic counselling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cases of recurrent pericentric inversions with euchromatic breakpoints were collected from Canadian Cytogenetic Laboratories. Cases included inversions for chromosome 1(p13q21), chromosome 2(p11.2q13), chromosome 5(p13q13) and chromosome 10(p11.2q21.2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of <jats:italic>de novo<\/jats:italic> inv(2)(p11.2q13) was low, with one case among 91 inversions. There were no cases of <jats:italic>de novo<\/jats:italic> inv(10) (p11.2q21.2) among 17 reported and one case of <jats:italic>de novo<\/jats:italic> inv(5)(p13q13) among 21 reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study, and data from the literature, suggests that most cases of inv(2)(p11.2q13) have been stably inherited, that <jats:italic>de novo<\/jats:italic> cases of inv(2) are rare and that both inherited and <jats:italic>de novo<\/jats:italic> forms are without phenotypic or developmental consequences. We suggest that parental karyotyping for cases of inv(2) is not useful in counselling as it may generate unnecessary parental anxiety over a chromosomal finding that is likely innocuous. Copyright \u00a9 2006 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.1508","type":"journal-article","created":{"date-parts":[[2006,7,6]],"date-time":"2006-07-06T03:35:30Z","timestamp":1152156930000},"page":"810-813","source":"Crossref","is-referenced-by-count":14,"title":["Prenatal cytogenetic assessment and inv(2)(p11.2q13)"],"prefix":"10.1002","volume":"26","author":[{"given":"Meaghan","family":"Hysert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne","family":"Bruy\u00e8re","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilbert B.","family":"C\u00f4t\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelika J.","family":"Dawson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u2010Anna","family":"Dolling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raouf","family":"Fetni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Hrynchak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9e","family":"Lavoie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"McGowan\u2010Jordan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Tihy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra M. V.","family":"Duncan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.37.11.858"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004390050609"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/316952"},{"issue":"3","key":"e_1_2_1_5_1","first-page":"129","article-title":"Pericentric inversions in man","volume":"29","author":"Groupe de Cytog\u00e9n\u00e9ticiens Fran\u00e7ais","year":"1986","journal-title":"Ann G\u00e9n\u00e9t"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00293869"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/426833"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.23.2605"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19991119)87:2<139::AID-AJMG5>3.0.CO;2-J"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00293042"},{"issue":"2","key":"e_1_2_1_11_1","first-page":"81","article-title":"Structural variation in chromosome No 9","volume":"17","author":"Madan K","year":"1974","journal-title":"Ann Genet"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1998.tb03696.x"},{"issue":"4","key":"e_1_2_1_13_1","first-page":"239","article-title":"Chromosome polymorphism in a human newborn population. 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